摘要
为研究聚乙二醇基氯硝柳胺衍生物体外抑制钉螺乙酰胆碱酯酶的活性,测定了氯硝柳胺衍生物抑制钉螺乙酰胆碱酯酶的半数抑制浓度IC50。结果表明:随着氯硝柳胺衍生物浓度的增加,对乙酰胆碱酯酶活性的抑制作用逐渐增强;随着聚乙二醇基链长的增加,药物对乙酰胆碱酯酶抑制活性依次减弱。
The concentrations causing 50% inhibition （IC50） of acetylcholinesterase （ACHE） activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomelania snail in vitro. Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects. With an increasing chain length of polyethylene glycol group linked on niclosamide, the inhibitory effects weakened.
出处
《化学试剂》
CAS
CSCD
北大核心
2009年第11期907-909,共3页
Chemical Reagents
基金
国家科技支撑计划重点课题(2009BAI78B012009BAI78B02)
江西省科技厅重大招标项目(2006)
江西省自然科学基金资助项目(2007GQH0366)
关键词
氯硝柳胺衍生物
聚乙二醇基
钉螺
乙酰胆碱酯酶
niclosamide derivatives
polyethylene glycol
Oncomelania snail
acetylcholinesterase
