摘要
目的观察博来霉素联合斑蝥酸钠维生素B6经中心静脉导管给药治疗恶性胸腔积液的临床疗效及安全性。方法66例恶性胸腔积液随机分为治疗组及观察组,均经中心静脉引流排净积液后给药,治疗组36例,经中心静脉导管给予博来霉素1mg/kgd1、8,斑蝥酸钠维生素B60.5mgd1、8胸腔内治疗,连续2周;对照组33例,给予博来霉素1mg/kgd1、8腔内治疗。结果观察组有效率91.5%(33/36),其中完全缓解63.8%(23/36),部分缓解27.7%;对照组有效率63.5%(21/33),其中完全缓解36.3%(12/33),部分缓解27.2%(9/33)。治疗组疗效优于对照组(P<0.05)。两组不良反应为轻度发热和胸痛,无显著性差异(P>0.05)。结论博来霉素联合斑蝥酸钠维生素B6经中心静脉导管给药治疗恶性胸腔积液疗效明显,不良反应轻微。
Objective To observe the efficacy and safety of bleomycin combination sodium cantharidinate and Vitamin B6 injection from central venous catheters for malignant pleural effusion. Methods 69 patients with malignant pleural effusion were randomly divided into treatment group and control group （bleomycin）. There are 36 patients in treatment group, 33 patients in control group. All patients were ti＇eated with bleomycin combination sodium cantharidinate and Vitamin B6 injection into pleural intreatment group, bleomycin was given to observation group. Results The treatment effectiveness of the observation group was 91.5%, and the treatment effectiveness of the control group was 63.5% （P〈0.05）. The major side effects were low fever, chest pain. There was no significent difference between the two groups （P〉0.05）. Conclusion Bleomycin combination sodium cantharidinate and Vitamin B6 injection is rather active and safe from central venous catheters in treating malignant pleural effusion.
出处
《当代医学》
2009年第34期147-148,共2页
Contemporary Medicine
