摘要
目的观察ABCG2和CD133在正常脑组织及胶质瘤中的表达及分布,分析和探讨二者在胶质瘤中表达的关系和意义。方法利用免疫组织化学方法,测定5例正常脑组织及59例胶质瘤中ABCG2和CD133的表达。结果①ABCG2与CD133在成人正常脑组织中无表达,在不同类型胶质瘤中有表达;②ABCG2与CD133阳性细胞率之间呈正相关(r=0.765,P<0.01);③ABCG2及CD133的阳性细胞率在多个病理级别之间有差异(P<0.05),在Ⅳ级胶质瘤中的表达最高。结论①ABCG2与CD133在成人正常脑组织中无表达,在不同类型胶质瘤中有表达;②ABCG2和CD133的表达可能促进了胶质瘤的发生与发展;③ABCG2、CD133的表达在不同胶质瘤病理级别之间有差异,为临床诊断胶质瘤、确定其恶性程度提供了依据。
[Objective] To observe the expression and distribution of ABCG2 and CD133 in human glioma, investigate their correlations with chnicopathological features of glioma. [ Methods ] The expression of ABCG2 and CD133 were determined by immunohistoehemical staining in 59 surgical specimens of human brain glioma and 5 normal brain tissue. [Results] ABCG2 and CD133 were expressed in all glioma specimens and weren＇t expressed in normal brain tissue. There was a siginificant correlation between ABCG2 group and CD133 group （r=-0.765, P〈0.01）. The fourth grade have higher positive cell rate than others. [ Conclusion ] ABCG2 and CD133 were expressed in all glioma specimens and weren＇t expressed in normal brain tissue. The positive expression of ABCG2 and CD133 may promote the development of glioma. Detecting the expression of ABCG2 and CD133 is helpful to evaluate the biological behavior of glioma, and also provides the evidence for chnic treatment.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第22期3425-3428,共4页
China Journal of Modern Medicine
