摘要
目的:了解近3年金华市妇幼保健院母血清产前筛查出生缺陷检出情况和筛查工作状况,为减少出生缺陷、提高工作质量提供依据。方法:采用时间分辨荧光法测定母血清二联标志物(甲胎蛋白AFP、游离β-HCG)来发现怀有先天缺陷胎儿的高危孕妇。结果:筛查15 383例对象中发现高风险孕妇751例,发生率为4.80%,确诊唐氏综合征(简称21—三体)6例,爱德华兹综合征(简称18—三体)3例,神经管畸形(NTD)5例,死胎6例,其他胎儿畸形12例。结论:产前筛查和产前诊断是减少出生缺陷的重要手段,产前筛查结合B超检查可提高出生缺陷的检出率。
ObjectiveTo understand maternal serum prenatal screening for birth deficiency detection and the work conditions of our hospital in the past three years,in order to provide evidence for reducing birth deficiency and improving the work quality.Methods Determination of maternal serum markers（alpha-fetoprotein AFP,free β-HCG） was adopted to find out high risk pregnant women of fetal birth deficiency by using time-resolved fluorescence method.Results By screening 15,383 cases of objects, we found among them 751 cases of high- risk pregnant women,incidence being ,4.80%,diagnosed 6 cases of Down＇s syndrome, 3 cases of Edwards syndrome, 5 cases of Neural tube defects, 6 cases of Stillbirth,and 12 eases of other fetal malformation. Conclusion Prenatal screening and prenatal diagnosis are important means to reduce birth deficiency, and prenatal screening combined with B- ultrasound examination can increase the detection rate of birth deficiency.
出处
《中国农村卫生事业管理》
2009年第11期870-872,共3页
Chinese Rural Health Service Administration
关键词
母血清产前筛查
出生缺陷
maternal serum prenatal screening
birth deficiency
