摘要
目的：对应用丙戊酸钠治疗的小儿癫痫患者进行临床决策分析。方法：采用荧光偏振免疫（FPIA）测定丙戊酸钠稳态谷浓度，用决策分析法分析504例服用丙戊酸钠小儿癫痫患者丙戊酸钠血药浓度与临床疗效及不良反应的关系。结果：丙戊酸钠血药浓度在50～110μg·L^-1时疗效好，不良反应轻。结论：丙戊酸钠治疗小儿癫痫的血药浓度治疗窗为50～110μg·L^-1。
OBJECTIVE To analyse the relationship between serum valproate level and its efficacy or side effects in children with epileptic. METHODS The serum valproate level was determined hy FPIA. Decision analysis was used to study the rela tionship between serum valproate level and the efficacy or side effects. RESULTS The efficacy of valproate in children with epileptic was best when the serum valproate levels were in the range of 50-110μg·L^-1,the severe side effect was found when the serum valproate levels were over 110 μg·L^-1. CONCLUSION It was suggested that the appropriate serum valproate level should be controlled within 50-110μg·L^-1 in childhood epileptic therapy.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第23期2017-2019,共3页
Chinese Journal of Hospital Pharmacy
基金
浙江省教育厅科技计划项目(编号:20061261)
关键词
丙戊酸钠
小儿
癫痫
决策分析
valproate children
epilepsy
decision analysis
