摘要
目的探讨重症急性胰腺炎(severe acute pancreatitis,SAP)继发胰腺感染的影响因素,以早期采取有针对性的干预措施,降低病死率。方法选择我院2004—2008年收治的36例重症急性胰腺炎患者,按有无继发感染分为两组,感染组与非感染组,先以单因素分析筛选有统计学意义的影响因素,再通过逐步Logistic回归分析筛选与继发感染有关的影响因素。结果两组患者中心静脉导管留置时间、禁食时间、有无低氧血症、胃肠道障碍时间、血清清蛋白水平方面差异有统计学意义(P<0.05)。重症胰腺炎患者继发胰腺感染相关因素的Logistic回归分析显示:中心静脉导管留置时间、禁食时间、有无低氧血症、胃肠道障碍时间与继发胰腺感染明显相关(OR值分别为1.17、1.41、1.37和1.58,P<0.05)。结论中心静脉导管留置时间、禁食时间、有无低氧血症、胃肠道障碍时间与继发胰腺感染明显相关。应引起注意,入院开始有针对性地进行干预,可减少病死率,改善预后。
Objective To study the risk factors of secondary pancreatic infection （SPI） in patients with severe acute pancreatitis （SAP） in order to take early intervention to reduce mortality. Methods Totally 36 diagnosed SAP patients from January 2004 to December 2008 were divided as SPI group and non-SPI group according to the secondary infection. Single factor analysis was taken to screen the statistically significant risk factors, and then stepwise Logistic regression analysis was used to determine the risk factors to secondary infection. Results There were significant differences between SPI group and non-SPI group in time of central veinous catheterization, fasting time, hypoxemia, time of gastrointestinal tract disorder, and level of serum albumin （P〈0.05）. Stepwise logistic regression analysis showed that the time of central veinous catheterization, fasting time, hypoxemia, and time of gastrointestinal tract disorder were remarkably associated with secondary pancreatic infection （OR=1.17, 1.41, 1.37 and 1.58 respectively, P〈0.05）. Conclusion The time of central veinous Catheterization, fasting time, hypoxemia, and time of gastrointestinal tract disorder were remarkably associated with secondary pancreatic infection. This should be pay attention to and given target intervention since beginning of hospitalization so as to reduce mortality and improve prognosis.
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第23期2165-2166,共2页
Chinese General Practice
关键词
重症急性胰腺炎
影响因素
预后
Severe acute pancreatitis
Influencing factors
Prognosis
