摘要
猪繁殖与呼吸综合征(PRRS)是猪繁殖与呼吸综合征病毒(PRRSV)引起的一种病毒性传染病,对养猪业造成严重威胁。对PRRSV的研究是兽医免疫学中最具挑战性的课题之一,至今人们对PRRSV所引起的免疫应答过程仍不十分了解。通过对PRRS的研究中获得的知识及存在问题的回顾,会对今后研究PRRS疫苗起到一定的推动作用。论文对PRRSV的获得性免疫反应、PRRSV的免疫调节及免疫逃逸、PRRSV的遗传多样性及其对疫苗开发的影响、现有疫苗防控措施、PRRSV疫苗的发展前景等方面的研究进展做了简要概述。
Porcine reproductive and respiratory syndrome virus（PRRSV） a member of Arterivirus Group, re- presents the causative agent of a new porcine disease which continues to be a threat for the pig industry. PRRS is one of the most challenging subjects of research in veterinary viral immunology, and the immune response against PRRS virus （PRRSV） is still poorly realized. Here we gave an overview of current knowledge and gaps that may be relevant for the development of a future generation of more effective vac- cines. The recent research progress on adaptive immune response to PRRSV,modulation and immune eva- sion, genetic diversity and implications for vaccine development, the existing control measures and prospects for the development of universal PRRSV vaccines were summarized.
出处
《动物医学进展》
CSCD
北大核心
2009年第12期94-99,共6页
Progress In Veterinary Medicine
基金
河北省科技攻关计划资助项目(20080106)
