摘要
目的探讨缺血性脑血管病患者颈动脉粥样硬化斑块的形成原因及其与同型半胱氨酸的相关性。方法对167例缺血性脑血管病患者采用彩色多普勒超声仪测定其颈动脉粥样硬化斑块的有无及其超声特征,测定内中膜厚度。检测其血清同型半胱氨酸、血脂、血清抗磷脂抗体及超敏C反应蛋白浓度。患者分为无斑块组和有斑块组。斑块组又分为稳定斑块亚组和不稳定斑块亚组。结果单因素分析年龄、高血压、脂代谢紊乱及同型半胱氨酸在无斑块组和有斑块组之间有显著性差别。Logistic回归分析只有年龄是斑块形成的独立危险因素。对于稳定和不稳定斑块亚组,Logistic回归分析只有颈动脉内中膜厚度是不稳定斑块形成的独立危险因素。无斑块组和斑块组的同型半胱氨酸浓度分别是13.0±6.8μmol/L和18.4±12.6μmol/L(P=0.042)。结论对于缺血性脑血管病患者,年龄是颈动脉粥样硬化斑块形成的独立危险因素,颈动脉内中膜厚度是颈动脉不稳定斑块形成的独立危险因素,血清同型半胱氨酸浓度与高血压、脂代谢紊乱一样是颈动脉粥样硬化斑块形成的非独立危险因素。
Objective To explore the generating cause of carotid atherosclerosis plaque and the correlation to serum homocysteine in patients of ischemic cerebrovascular disease.Methods All 167 patients with ischemic cerebro-vascular disease were received carotid ultrasonography screening.To all patients intima-media thickness,serum homocysteine,lipids,serum antiphospholipid,and high-sensitivity C-reactive protein were assessed.Patients were classified into two groups：plaque group and no plaque group.Plaque group was divided into two subgroups：stable and unstable.Results Through one fator analysis,age,hypertension,dyslipidemia and homocysteine showed differences between these two groups.Logistic regression showed that only age was the independent risk fator for carotid plaque.To stable and unstable plaque subgroups,through logistic regression analysis,only intima-media thickness was the independent risk fator for carotid unstable plaque.Serum homocysteine for no plaque group and plaque was 13.0±6.8μmol/L and 18.4±12.6μmol/L,respectively.Conclusion To patients with ischemic cerebrovascular disease,age is the independent risk fator to carotid plaque and intima-media thickness is the independent risk fator to unstable carotid plaque and homocysteine.Like the hypertension and dyslipidemia,Serum hemocysteine is the un-independent risk fator to carotid plaque.
出处
《脑与神经疾病杂志》
2009年第6期409-411,共3页
Journal of Brain and Nervous Diseases
基金
吴阶平医学基金会临床科研专项资助基金(320)
