摘要
目的探讨丹参抗大鼠乙酸胃溃疡和防止复发的效果及机制．方法在大鼠乙酸胃溃疡急性期用丹参治疗，并与传统的抗溃疡药西咪替丁相对比，采用Ｋｅｒｓ等法测定胃粘膜表面凝胶厚度，应用传统的体外掺入氚胸腺嘧啶（３ＨＴｄＲ）于胃粘膜的放射性自显影方法测定胃粘膜细胞的标记率（ＬＲ），同时观测ｄ５、ｄ３０、ｄ１２６的溃疡指数（ＵＩ）、溃疡抑制率（ＩＲ）与凝胶的厚度、ＬＲ的关系．结果丹参组的ＵＩ低于西咪替丁组（４２３±３９，３６±１２，４４±２３；４９１±３６，５９±１４，９２±１３，Ｐ＜００１）；西咪替丁组的低于对照组（６１０±３８，８９±２５，１２４±２４，Ｐ＜００１）；丹参组的ＩＲ（％）高于西咪替丁组（３１，５９，６５；１９，３３，２６）；丹参组的凝胶厚度（μｍ）高于西咪替丁组（４５±３，６０±３，５８±２；３６±４，４７±４，４１±３，Ｐ＜００１），西咪替丁组的高于对照组（２２±６，３５±３，２８±５，Ｐ＜００１）；丹参组的ＬＲ（％）高于西咪替丁组（１００±０５，１６２±０８，１５０±０６；９０±０５，１３９±０６，１０８±０７，Ｐ＜００１）、西咪替?
IM To study the effect of Danshen (Radix Saliva Miltiorrhizae) in prevention and treatment of rat acetic acid gastric ulcer. METHODS Rat acetic acidinduced gastric ulcer was treated with Danshen in the acute period, and compared with cimetidine in gel thickness of gastric mucosa surface (Kerss method), and 3HTdR label rate (IR) of gastric mucosa in vitro on day 5, 30 and 126, ulcer index (UI), ulcer inhibitory rate (UR). RESULTS UI of Danshen group was lower than cimetidine group (423±39,36±12,44±23 vs 491±36,59±14,92±13,P<001), and the control group (610±38, 89±25,124±24,P<001);IR(%) of Danshen group was higher than cimetidine group (31,59,65 vs 19,33,26);gel thickness (μm) of Danshen group was higher than cimetidine group (45±3,60±3,58±2 vs 36±4,47±4,41±3,P<001) and the control group (22±6,35±3,28±5,P<001); LR(%) of Danshen group was higher than cimetidine (100±05,162±08,150±06 vs 90±05,139±06,108±07,P<001); and control group and (65±07,101±05,80±07,P<001); and UI of Danshen group between day 30 and 126 was not different. CONCLUSION Danshen can promote ulcer healing and prevent recurrence, through strengthening the gastric mucus and mucosal barriers. .
基金
国家自然科学基金资助项目,No.39070961.
关键词
丹参/药理学
胃溃疡/中医药疗法
复发
乙酸
saliva miltiorrhiza/pharmacology
stomach ulcer/zhong yi yao liao fa
recurrence
acetic acid
