摘要
目的探讨超声测量胎儿颈背皮肤透明带厚度(nuchalskinfold thickness,NT)在染色体异常疾病21-三体综合征筛查的应用价值。方法经腹超声测量孕12～27周孕妇1500例胎儿颈背皮肤透明带厚度,并与染色体核型分析及随访后结果作对照。结果1500例胎儿中,21-三体综合征的发病率为3.3‰,其中NT增厚者有62例,其中4例为21-三体综合征;无NT增厚中,有1例21-三体综合征。敏感性为80%,特异性为96.07%,准确性为96.12%,阳性预测值为6.45%。结论NT检测对于21-三体综合征的早期诊断具有重要的意义,是早中期妊娠阶段产前筛查有效可行的方法。
Objective To assess the value of nuehalskinfold thickness （NT） by ultrasonic B in screening Down syndrome at early and middle stage pregnancy. Methods Nuehalskinfold thickness （NT） of 1500 pregnant women （12 - 27weeks） were detected by ultrasonic B, and results were compared with chromosomal karyotypes analysis and follow-up visit of each pregnant woman. Results In 1 500 eases incidence of Down syndrome was 3.3‰, and 62 cases were high-risk for NT by ultrasonic B and including 4 Down syndrome cases ;in low-risk for NT cases, 1 Down syndrome case were found. The NT sensitivity to Down syndrome was 80%, specificity was 96. 07%, accuracy was 96. 12% and the positive predictive rate was 6.45%. Conclusion Detection of NT by ultrasonic B may play an important role in screening Down syndrome at early and middle stage pregnancy.
出处
《中国临床新医学》
2009年第12期1236-1238,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西壮族自治区科技厅科技攻关与开发资助项目(桂科攻9817095)
关键词
21-三体综合征
B超
NT
产前筛查
Down syndrome
Ultrasonic B
Nuchalskinfold thickness （NT）
Postnatal screening
