摘要
目的观察超短波联合电针对家兔实验性膝关节骨性关节炎的治疗作用并探讨其机制。方法将55只日本大耳白兔随机分出10只为空白对照组,余45只采用右后肢膝关节伸直位固定6周的方法建立膝关节骨性关节炎模型。将造模成功的40只家兔随机分为模型对照组、电针治疗组、超短波治疗组、联合治疗组,每组10只。电针治疗组选取家兔右后肢血海、梁丘、阳陵泉和足三里穴,毫针针刺后接电针治疗仪治疗25min,超短波治疗组使用超短波机治疗20min,联合治疗组联合采用电针和超短波治疗,各组均每日治疗1次,在治疗30天后测定兔血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的含量以及测量家兔右后肢膝关节活动度。结果电针治疗组、超短波治疗组、联合治疗组同模型对照组比较血清中SOD显著升高,NO、MDA显著降低,关节活动度改善(P<0.01);并且联合治疗组优于超短波治疗组和电针治疗组(P<0.01)。结论超短波联合电针治疗家兔膝关节骨性关节炎疗效肯定并优于单纯的超短波疗法和电针疗法,其作用机制可能与改善自由基代谢有关。
Objective To investigate the therapeutic effect and mechanism of ultrashort-wave therapy combined with electroacupuncture on the experimental rabbits with knee osteoarthritis. Methods Ten of fifty-five experimental Japanese big-ear rabbits were randomized into the blank control group, and the other 45 were made knee osteoarthritis models by prolonged fixation of the right posterior knee joint in extension for 6 weeks. The 40 successfully made models were randomized into model control group, electroacupuncture group, ultrashort-wave group, and combined electroacupuncture and ultrashort-wave group, 10 in each. The electroacupuncture group was treated with electroacupuncture at Xuehai （SP 10）, Liangqiu （ST 34）, Yanglingquan （GB 34）, and Zusanli （ST 36） of the right posterior leg, the ultrashort-wave group was treated with ultrashort-wave therapy, and the combined elec- troacupuneture and ultrashort-wave group was treated with electroacupuncture and ultrashort-wave therapy, each time 25rain, once a day. After treatment for 30 days, the levels of superoxide dismutase （SOD）, malondialdehyde （MDA）, and nitric oxide （NO） in serum and the movement of affected knee joint were measured respectively in each group. Results Compared with the model control group, there was a significant increase of SOD, decrease of NO and MDA and knee movement improvement in the electroacupuncture, ultrashort-wave, and combined groups （P 〈0. 01）, and the effect of the combined group was better than that of ultrashort-wave and electroacupuncture groups （P〈 0. 01 ）. Conclusion The ultrashort-wave therapy combined with eleetroacupuncture therapy is effective for knee osteoarthritis of rabbits, and is better than that of single use of ultrashort-wave therapy and electroacupuncture. The functional mechanism is possibly related with the improvement of metabolism of free radicals.
出处
《中医杂志》
CSCD
北大核心
2010年第1期52-54,共3页
Journal of Traditional Chinese Medicine
关键词
电针
超短波
膝关节骨性关节炎
自由基
家兔
Electroacupuneture
Ultrashort-wave therapy
Knee osteoarthritis
Free radicals
Rabbits
