摘要
目的评价辛伐他汀治疗对冠状动脉粥样斑块的影响。方法对73例经64层螺旋CT及回顾性心电门控技术检测出的冠脉粥样斑块患者,给予辛伐他汀40mg/d口服,18个月后复查斑块情况。同时随访患者的血脂水平。结果73例患者接受辛伐他汀调脂治疗后总胆固醇(TC)降低15.4%,LDL-C下降25.3%,TG下降14.2%,HDL-C增加8.5%。有202支冠状动脉存在224个粥样斑块,治疗后各种斑块大小有不同程度的缩小,其中脂质斑块(74个)缩小幅度25.4%(P<0.05);纤维斑块(58个)缩小幅度14.3%(P<0.05);混合斑块(47个)缩小幅度12.7%(P<0.05);而钙化斑块(45个)缩小幅度不明显(3.8%,P>0.05)。结论本试验证实长期服用辛伐他汀能够有效降低血脂水平,逆转或稳定冠脉粥样斑块,从而降低急性冠状动脉事件。
Objective To evaluate the effects of simvastatin on coronary atheroma. Methods Seventy-three cases of coronary atheroma were examined with 64-slice spiral computed tomography, received simvastatin tablets （40 mg/ d） for 18 months and scaning coronary atheroma again after 18 months. Results Among the 73 cases, 15.4% had reduction in serum cholesterol,25.3 % reduction in low-density lipoprmein cholesterol,and 8.5 % increase in high-density lipoprotein cholesterol. 224 cases of coronary atheroma occurred in 202 coronary artery branches. The sizes of all plaques had different degrees of descent after the treatment. The rate of descent was 25.4% in 74 tipoid plaques （P〈0.05） ,14.3% in 58 fibrous plaques （P〈0.05） ,12.7% in 47 mixed plaques（P〈0.05） ,3.8% in 45 calcified plaques（P〉0.05）. Conclusion Simvastatin given daily over eighteen months can reduce hyperlipidaemia,slow progression of coronary atheroma and improve the clinical outcomes. 64 slice spiral computed tomography can quantitatively evaluate the changes of coronary atheroma. It provides the objective basis for clinic treatment.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第2期193-194,196,共3页
Chongqing medicine
关键词
辛伐他汀
冠状动脉疾病
斑块
体层摄影术
螺旋计算机
coronary artery disease
simvastatin
coronary atheroma
tomography
spiral computed
