摘要
目的观察肝硬化患者T细胞免疫功能和肠源性内毒素血症之间的关系。方法选取肝硬化患者40例,正常对照组20例,检测其血清中内毒素(ET)、CD3、CD4、CD8水平,并分析其相关性。结果与正常对照组比较,肝硬化组血清ET水平显著升高;CD3、CD4、CD4/CD8均明显下降,CD8明显升高;ET水平与CD3、CD4、CD4/CD8水平呈负相关,与CD8的表达呈正相关。结论肝硬化患者体内血清内毒素水平明显升高,且同时伴有显著的细胞免疫功能低下,两者呈明显负相关。
Objective To investigate the relationship between endotoxemia and cellular immunity in patients with liver cirrhosis.Methods Forty liver cirrhosis patients and 20 normal controls were chosen,and the levels of serum endotoxin,CD3,CD4,CD8 were detected.The relationship was analyzed by statistical method.Results Compared with normal controls,the levels of serum endotoxin and CD8 increased significantly,while the percentages of CD3,CD4 and the ratio of CD4/CD8 decreased markedly in liver cirrhosis patients.The serum endotoxin level had a positive correlation with CD8,while it had the remarkable negative correlation with the percentages of CD3,CD4 and the ratio of CD4/CD8.Conclusion The level of serum endotoxin in patients with liver cirrhosis increases,while cellular immunity decreases.There exists the remarkable negative correlation.
出处
《胃肠病学和肝病学杂志》
CAS
2010年第1期31-32,共2页
Chinese Journal of Gastroenterology and Hepatology
