摘要
目的探讨外周血中炎性标志物红细胞沉降率（ESR）和血清C反应蛋白（CRP）水平与肺癌患病风险的关系。方法选取103例初次确诊的肺癌患者（肺癌组）和同期住院的85例常见慢性呼吸道疾病患者（对照组），治疗前检测外周血中ESR、CRP、癌胚抗原（CEA）、糖类抗原125（CA125）和糖类抗原19-9（CA19-9）水平。应用多因素Logistic回归，分析ESR和CRP水平与肺癌临床病理特征及其肺癌患病风险的关系。结果肺癌组ESR和CRP水平分别为（40．03±30．85）mm／h和14．70mg／L，显著高于对照组[（23．47±15．33）mm／h和8．50mg／L，P〈0．001]。ESR和CRP水平与肺癌的分期、分型无明显相关（P〉0．05）。ESR与CRP呈正相关（r=0．56，P〈0．001），ESR与CA125（r=0．33，P〈0．001）、CRP与CA125（r=0．32，P〈0．001）呈正相关。调整患者年龄、性别和吸烟状况等因素，多因素Logistic回归分析结果显示，CRP水平与肺癌患病风险显著相关，并且随着CRP水平的增加，肺癌的患病风险增加。与CRP水平第1分位患者比较，第2分位患者的患病风险增加2倍（OR为2．46，95％CI为1．16—5．20），第3分位患者的患病风险增加10倍（OR为10．52，95％口为4．40～25。18）。ESR水平与肺癌患病风险无关。结论ESR水平与肺癌患病风险无关。血清CRP水平与肺癌的患病风险密切相关，提示其对筛查肺癌高危人群具有潜在应用价值。
Objective To explore the association between the erythrocyte sedimentation rate, serum C-reactive protein （CRP） and the risk of lung cancer. Methods One hundred and three patients with newly diagnosed lung cancer and 85 homochronous hospitalized patients with chronic respiratory diseases （including chronic obstructive pulmonary disease, asthma, bronchiectasis and pulmonary fibrosis ） were included in this study. ESR, serum levels of CRP, CEA, CA19-9 and CA125 were analyzed in the two groups before the initiation of any therapy after hospitalization. The association with clinicopathological characteristics of lung cancer and the risk of lung cancer were estimated by logistic regression. Results Both the ESR and CRP levels were significantly higher in the lung cancer group, as compared with that in the chronic respiratory diseases group （ P 〈 0. 001 ）. There was no significant association of ESR and CRP with lung cancer stage and type. Spearman correlation analysis showed a positive correlation between ESR and CRP （r=0. 56,P〈0. O01）, ESR and CA125 （r =0.33,P〈0.001）, and CRP and CA125 （r =0.32,P〈 0. 001 ）. The results of multivariate logistic analysis showed that the level of CRP was associated with an increased risk of lung cancer. Adjusting the confounding factors such as age, gender and smoking condition, the risk increased along with the elevation of CRP. Compared with the first quantile patients, the risk of the second quantile patients increased twice （ OR：2.46, 95% CI：1.16-5.20）, the risk of the third quantile patients increased ten-fold （ OR： 10. 52, 95% CI： 4.40-25.18 ）. Conclusion The level of CRP is associated with an increased risk of lung cancer. The results of this study suggest that early detection of CRP may have a potential predicting value for high risk group of lung cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2010年第1期48-51,共4页
Chinese Journal of Oncology
