摘要
目的：了解术前局部注射高三尖杉酯碱联合地塞米松对减少翼状胬肉术后复发的效果。方法：将７２例翼状胬肉患者分为两组，治疗组４２例４２眼，术前７、３及１ｄ翼状胬肉局部注射１．８×１０－４ｍｏｌ／Ｌ高三尖杉酯碱０．２ｍＬ加９．６８×１０－３ｍｏｌ／Ｌ地塞米松０．２ｍＬ的混合液共约０．４ｍＬ，对照组３０例３０眼术前不用药。分别观察术后眼部反应、复发率及行增殖细胞核抗原（ＰＣＮＡ）免疫组化研究。结果：平均术后随访１８．２月，术后复发率分别为，治疗组４．７６％（２／４２），对照组２３．３３％（７／３０），二组比较差异有显著性（Ｐ＜０．０５）。病理结果显示，治疗组ＰＣＮＡ阳性率为（５．５９±３．８２）％，对照组阳性率为（１１．５±３．６２）％，二组比较差异有显著性（Ｐ＜０．０５）；二组皆未见毒副作用。
Objective: To study the effect of homoharringtonine and dexamethasone injection of topical pterygium before excision on the prevention of recurrence of pterygium.Methods: 72 patients with pterygium were randomly divided to two groups: the treatment group ( n =42) received 1.8×10 -4 mol/L homoharringtonine 0.2 mL and 9.68×10 3 mol/L dexamethasone 0.2 mL injection of topical pterygium 7,3, and 1 day respectively before surgical excision,but the control group ( n =30) did not receive the injection of the above drugs . The surgical methods and postoperative treatment were the same between the two groups.The postoperative reaction and recurrence rate were observed ,and the proliferationg cell nuclear antigen (PCNA) were immunohistochemically studied. Results: After follow up check of mean 18.2 months ,the recurrence rate was significantly lower in treatment group than that in control group [4.76%(2/42) vs 23.33%( 7/30), P <0.05]. The immunohistochemical study showed that the PCNA positive rates were (5.59±3.82)% in the treatment group and 11.5±3.62% in control group ( P < 0.05 ). No severe complications occurred in the two groups. Conclusion: The homoharringtonine and dexamethasone injection of topical pterygium before excision was effective for decreasing the recurrent pterygium.
出处
《广东医学院学报》
1998年第4期324-326,共3页
Journal of Guangdong Medical College
基金
广东省医学科学技术研究基金
