摘要
目的阐释金玄痔科熏洗散抗炎和镇痛作用的物质基础。方法采用蛋清致大鼠足跖肿胀实验及二甲苯致小鼠耳廓肿胀实验,观察金玄痔科熏洗散提取纯化物质的抗炎作用;并采用热板致痛实验观察其对小鼠的镇痛作用。结果金玄痔科熏洗散方中的超临界CO2萃取物、皂苷与黄酮合提物和矿物药分别对蛋清所致大鼠足跖肿胀具有消肿作用,皂苷与黄酮合提物对二甲苯所致小鼠耳廓肿胀的急性炎症模型有显著抑制作用,3种药物组分均对热刺激所致小鼠疼痛有明显的镇痛作用,可显著提高痛阈值。结论金玄痔科熏洗散有效部位群为超临界CO2萃取物、皂苷与黄酮合提物和矿物药。
Objective To explain the material foundation of anti-inflammatory and analgesic effects of dinxuan Zhike Xunxi San. Methods The foot swelling experiments in rat and xylene-induced ear edema experiments in mouse were adopted to observe the anti-inflammatory effects of the material extracted and purified from dinxuan Zhike Xunxi San. The hot plate-induced pain experiment for studying the analgesic effect was established. Results The material of supercritical CO2 extract, saponins and flavonoids extract and minerals in dinxuan Zhike Xunxi San had a inhibiting effect on egg-induced foot swelling in rat, saponins and flavonoids extract had a distinct inhibiting effect on xylene-induced ear edema in mouse. Every extract had obvious analgesic effects on hot plate-induced pain and significantly increased the threshold of pain. Conclusion The active ingredient groups of dinxuan Zhike Xunxi San are the material of supercritical CO2 extract, saponins and flavonoids extract and minerals.
出处
《中国中医药信息杂志》
CAS
CSCD
2010年第2期35-37,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
马应龙药业集团肛肠基金资助(200808)
关键词
金玄痔科熏洗散
抗炎镇痛
超临界CO2萃取物
皂苷与黄酮合提物
矿物药
dinxuan Zhike Xunxi San
anti-inflammatory and analgesic
the material of supercritical CO2 extract
the saponins and flavonoids extract
minerals
