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骨关节炎和骨质疏松:骨髓间充质干细胞与成骨细胞 被引量：2

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摘要 骨关节炎和骨质疏松是最常见的两种骨代谢异常疾病。骨髓间充质干细胞和成骨细胞广泛存在于骨髓及松质骨中,对骨代谢有重要作用。本文对近年关于骨髓间充质干细胞和成骨细胞与这两种疾病关系的研究结果进行一综述,分析这两类细胞在不同骨代谢异常中的特点,以此增加对骨关节炎和骨质疏松发病机制的认识,希望能为临床更有针对性诊疗和预防骨代谢异常疾病提供一定帮助。
作者 金文杰 戴力扬
机构地区 上海交通大学医学院附属新华医院骨科
出处 《中国骨与关节外科》 2009年第6期499-504,共6页 Chinese Journal of Bone and Joint Surgery
基金 上海市科委重点项目(08JC1415800 08411950100)
关键词 骨关节炎 骨质疏松 骨髓基质干细胞 骨细胞 骨代谢
分类号 R684.3 [医药卫生—骨科学] R580 [医药卫生—内分泌]
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参考文献51

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同被引文献85

  • 1霍建忠,陈峥嵘,蒋淳,郭常安,朱列伟,高飞.转化生长因子-β_1基因修饰骨髓间充质干细胞复合壳聚糖修复兔关节软骨缺损[J].中华风湿病学杂志,2005,9(7):393-396. 被引量：8
  • 2王家双.膝关节骨性关节炎病因与诊治进展[J].广东医学,2006,27(1):4-6. 被引量：25
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  • 6Filardo G,Madry H,Jelic M. Mesenchymal stem cells for the treatment of cartilage lesions:from preclinical findings toclinical application in orthopaedics[J].{H}Knee Surgery Sports Traumatology Arthroscopy,2013,(08):1717-1729.
  • 7MacFarlane RJ,Graham SM,Davies PS. Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases:potential for treatment[J].{H}EXPERT OPINION ON THERAPEUTIC TARGETS,2013,(03):243-254.
  • 8Veronesi F,Giavaresi G,Tschon M. Clinical use of bone marrow,bone marrow concentrate,and expanded bone marrowmesenchymal stem cells in cartilage disease[J].{H}STEM CELLS AND DEVELOPMENT,2013,(02):181-192.
  • 9Diekman BO,Wu CL,Louer CR. Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis[J].cellTransplant,2013,(08):1395-1408.
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中国骨与关节外科
2009年 第6期

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