摘要
目的观察老年慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者骨密度（BMD）、肺功能和血气分析的变化，探讨老年COPD与继发性骨质疏松症的关系。方法用双能X线吸收测定仪测定32例老年男性COPD患者腰椎（L1-4）、股骨近端[颈部（Neck）、大粗隆（Troch）、合计（Total）]BMD，同时用肺功能仪测定肺功能，血气分析仪测量动脉血气分析，以及生化、血钙等检查。结果COPD组的BMD值与对照组相比显著降低（P〈0．001），COPD患者BMD与第1秒用力呼气容积占预计百分比呈显著正相关（P〈0．001）。结论老年COPD组BMD低于对照组。COPD是继发性骨质疏松症的患病因素之一。老年COPD患者BMD检查能及早发现骨质疏松。低氧血症可能是老年COPD患者合并骨质疏松症的主要危险因素。
Objective To observe the change of bone mineral density（BMD）, lung function, and arterial blood gas analysis among the senior with chronic obstructive pulmonary disease（COPD）and study the relevance between COPD and secondary osteoporosis. Methods BMD in lumbar vertebrae from first to forth and proximal femur of 32 old male patients with COPD was measured by dual-energy X-ray absorptiometry. Lung function and arterial blood gas analysis of those were also tested respectively by pulmonary function instrument and blood gas analyzer. The other measurement items included biochemistry,serum calcium and so on. Results The level of BMD in the group of patients with COPD was much lower than that in control group （ P 〈 0. 001）. BMD was significantly positively related to forced expiratory volume in one second among patients with COPD（ P 〈0. 001 ）. Conclusions BMD in the group of patients with COPD was lower than that in control group. COPD is one of the risk factors of secondary osteoporosis. In order to early check for osteoporosis,BMD of old people with COPD should be measured. Hypoxemia might be the major risk factor which can results in osteoporosis in the senior suffering from COPD.
出处
《国际呼吸杂志》
2010年第5期263-265,共3页
International Journal of Respiration
关键词
老年慢性阻塞性肺疾病
低氧血症
骨质疏松
骨密度
Chronic obstructive pulmonary disease
Hypoxemia
Osteoporosis
Bone mineral density
