摘要
目的对5种药物的血药浓度监测数据进行统计分析，为临床合理用药提供参考。方法采用EMIT方法测定口服卡马西平、丙戊酸、苯妥英或苯巴比妥的癫痫患者和服用地高辛的心衰患者的血药浓度，对798例患者889侧次TDM结果进行分析。结果5种药物血药浓度在治疗窗内的占44．99％；低于治疗窗浓度的占35．77％；高于治疗窗浓度的占19．24％；血药浓度在治疗窗内的比例，卡马西平最高（56．15％），苯妥英最低（4．82％）；低于和高于治疗窗的，苯妥英所占比例是最高的，分别是69．88％和25．30％。结论血药浓度监测结果是指导临床合理用药的依据之一，应综合分析患者用药方案，实验室数据和疗效，真正做到个体化给药。
Objective To analyse the therapeutic drug monitoring （TDM） data of 5 drugs and provide reference for rational administration. Methods EMIT was used to determine the blood concentration of oral carbamazepine, valproic acid, phenytoin and phenobarbital in epileptic patients,and of oral digoxin in congestive heart failure patients. Retrospective analysis was performed upon the TDM data of 889 samples from 798 patients. Results 44.9% of all the data fell within the therapeutic windows, 19. 24% were higher than the upper limits and 35.77% were less than the lower limits. Comparing the percentages of the concentration failing within therapeutic window among different drugs,Carbamazepine was highest （56.15%） and Phenytoin （PHT） was the lowest （4.82%）. There were 69. 88% PHT concentration data higher the upper limit and 25.30% less than the lower limit,and both the them were the highest among different drugs. Conclusion TDM is one of the hases for guiding clinical rational administration. Should comprehensively analyse adminstration schema,data from laboratory and clinical effect in order to make the indiviual administration come true.
出处
《现代检验医学杂志》
CAS
2010年第1期138-140,共3页
Journal of Modern Laboratory Medicine
