摘要
目的：观察宽叶缬草（ＶａｌｅｒｉａｎａＯｆｉｃｉｎａｌｉｓＶａｒＬａｔｉｆｏｌｉａＭｉｑ，ＶＯＬ）油对实验性高血脂家兔血脂代谢的影响。方法：３２只健康雄性大耳白兔采用免疫损伤合并高胆固醇喂饲４５ｄ，复制高脂血症和动脉粥样硬化（Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ，ＡＳ）模型，然后随机分为四组（每组８只）：（１）动脉粥样硬化模型对照组（ＣＡＳ组）；（２）小剂量ＶＯＬ组（ＶＯＬ１组）；（３）大剂量ＶＯＬ组（ＶＯＬ２组）；（４）舒降之组（Ｓｉｍｖａｓｔａｔｉｎ，ＳＴ组）。继续喂养６０ｄ。于实验前、实验第４５、７５、１０５ｄ分别抽血检测血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。结果：ＶＯＬ油能显著降低ＴＣ、ＴＧ、ＬＤＬ－Ｃ，升高ＨＤＬ－Ｃ，ＶＯＬ２组及ＳＴ组与ＣＡＳ组比较差异有显著性（Ｐ＜０．０１，Ｐ＜０．０５）；ＶＯＬ１组与ＳＴ组比较无显著性差异（Ｐ＞０．０５）。
Objective:To evaluate the effects of valeriana officinalis varlatifolia miq(VOL) oil on the blood lipid metabolism in experimental hyperlipidemic rabbits.Methods:Injured by immunoreaction and fed with 1.5% cholesterol diet for 45 days,the 32 male rabbits were randomly divided into four groups(8 in each): atherosclerosis control group (CAS, fed with common diet),low-dose VOL group(VOL 1, common diet + VOL oil 150 mg/day). High-dose VOL group (VOL 2,common diet + VOL oil 500 mg/day), simvastatin group (ST, common diet + ST 5mg/day).The experiment lasted 105 days.Blood samples were collected before the experiment and 45 days, 75 days and 105 days after the experiment from all the rabbits for measurement of serum total cholesterol (TC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) respectively.Results:TC,TG and LDL-C were significantly lowered in VOL 2 and ST groups(P<0.01,P<0.05),compared with CA group.Serum lipid had no significant differences in VOL 1 group,compared with ST group(P>0.05).Conclusion:VOL oil plays a significant role in the modification of lipid.
出处
《郧阳医学院学报》
1998年第3期131-133,共3页
Journal of Yunyang Medical College
