摘要
目的探讨贝那普利对高血压合并糖耐量低减（1GT）患者血管内皮依赖性舒张功能的影响。方法贝那普利10～20mg／d治疗高血压合并IGT患者40例，共6个月，分析治疗前后血压、空腹血糖（FPG）、糖负荷后2h血糖（2hPG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA—IR）、血浆一氧化氮（NO）的变化，利用高频超声血管技术检测贝那普利治疗前后肱动脉内皮依赖性舒张功能（EDD），计算其舒张内径的变化率（D）。结果与治疗前比较，治疗后患者的收缩压下降（P〈0．01），舒张压、FINS、HOMA—IR下降（P〈0．05），血浆NO水平、D升高（P〈0．05）。治疗前后D变化值（AD）分别与FINS、HOMA—IR、NO及它们的变化值AFINS、AHOMA—IR、ANO相关。结论贝那普利对高血压合并IGT患者在有效降压的同时，能明显改善内皮依赖性舒张功能。
Objective To explore the effects of benazepril on endothelium-dependent diastolic （EDD） function of brachial artery in hypertension patients with impaired glucose tolerance （IGT）. Methods Forty hypertension patients with IGT were treated with benazepril 10-20 mg/d for six months. Before and after treatment, blood pressure, fast plasma glucose （FPG）, 2-hour plasma glucose （2-h PG）, fast insulin （FINS）, insulin resistance index （HOMA-IR） , nitrogen monoxidum （NO） were determined. High-frequency ultrasonic imaging was used to detect the changes of brachial artery EDD function after administration with benazepril, then calculate diastolic inner diameter changing rate （D）. Results Compared with pretherapy, the systolic blood pressure was reduced （P 〈0.01 ）. The diastolic blood pressure, FINS, HO- MA-IR were decreased （P 〈0.05 ）. The plasma NO and D were increased （P 〈0.05 ）. Before treatment, D was correlated with FINS, HOMA-IR and plasma NO, the change of D before and after treatment was correlated with the change of FINS, HOMA-IR and plasma NO. Conclusions Benazepril can reduce the blood pressure, improve EDD function in hypertension patients with 1GT.
出处
《山东医药》
CAS
北大核心
2010年第8期29-31,共3页
Shandong Medical Journal
关键词
高血压
糖耐量
贝那普利
内皮依赖性舒张功能
hypertension
glucose tolerance
benazepril
endothelium-dependent diastolic function
