摘要
舒洛地特是一种新型天然糖胺聚糖,含有的两个主成分作用原理不同而协同增效,具有抗凝、溶栓、抗心血管疾病、降血脂、保护肾脏等作用,近年来在治疗心血管疾病、周围动脉疾病、静脉炎后综合征、糖尿病并发症,尤其糖尿病肾病等方面的临床应用引起了人们的关注,本文就其化制与药理、临床研究与应用,以及近年来的研究进展进行综述。与同类药肝素比,舒洛地特由于可口服,生物利用率高,副作用小,并具有肝素所没有的分解脂肪作用,可以认为应用将更广泛。目前国内只有进口产品,国内厂家正处于研发阶段,相信不久将来会有国产舒洛地特。
Sulodexide is a new type of natural glycosaminoglycans, contains two main components to different synergistic action principle, with anticoagulation, thrombolysis, anti-cardio- vascular disease, reducing blood lipid, protecting the kidneys and other role, In recent years, in the treatment of cardiovascular disease, peripheral artery disease, post-phlebitis syndrome, complications of diabetes, especially diabetic nephropathy, etc. The clinical application attracted attention, this article on its chemical composition, pharmacokinetics, biological activity, quality control, mechanism and pharmacology, clinical research and applications, and recent research are reviewed. To be compared with similar drugs heparin, sulodexide to special due to be taken orally, the bioavailability of high, fewer side effects, and with heparin no role of the decomposition of fat can be considered more widely applied. Currently only the imported products, domestic manufacturers are in research and development stage, I believe that in the near future will be made to sulodexide in china.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2010年第1期109-115,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
舒洛地特
低分子肝素
硫酸皮肤素
抗血栓
心血管疾病
糖尿病肾病
Sulodexide
Low molecular weight heparin
Dermatan sulfate
Anti-throm-bosis
Cardiovascular disease
Diabetic nephropathy
