摘要
近年来随着人们物质生活水平的提高,高血压、血脂异常、糖尿病、吸烟、肥胖等心血管疾病的危险因素逐渐增多,动脉粥样硬化性心血管疾病已经成为现在人类主要死亡原因之一。众所周知,他汀类药物是治疗高血脂疾病的首选药物,随着科研的进步,越来越多的实验数据表明,他汀类药物具有独立的降压作用,它主要通过改善细胞内皮功能,下调血管紧张素Ⅰ型受体,调节细胞色素P450酶的代谢途径从而达到降压的效果。
In recent years,with the improvement of material standards of human life,hypertension,dyslipidemia,diabetes,smoking,obesity and other risk factors for cardiovascular disease are gradually increasing.Atherosclerotic cardiovascular disease has become one of the major causes of death.It is well known that statin drugs are the first choice for treating high blood lipid disease.Along with scientific advance,more and more experimental data indicate that statins have independent effect of lowing blood pressure.It can achieve the effect mainly by improving endothelial function in cells,reducing angiotensinI（ATI）receptor,and regulating metabolic pathways of Cytochrome P450 enzymes.
出处
《医学综述》
2010年第5期725-727,共3页
Medical Recapitulate
