期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA依赖性蛋白激酶在妇科肿瘤中的研究进展

The Latest Development of Dna-PK in Gynecologic Oncology
在线阅读 下载PDF
导出
摘要 DNA依赖蛋白激酶(DNA-PK)是哺乳动物细胞DNA损伤修复的关键酶。研究表明,妇科肿瘤,如宫颈癌、卵巢癌中普遍存在DNA-PK表达的变化,提示该酶在妇科肿瘤的发生、发展过程中发挥着重要的作用,并与肿瘤的临床分期、放射敏感性和预后有重要关系。近年来,关于DNA-PK的结构与功能、在肿瘤细胞株中的活性、在肿瘤组织中表达的研究日益深入,以DNA-PK为靶点的DNA修复抑制剂作为肿瘤放化疗增敏药已陆续研发并进入临床前试验,有望成为肿瘤诊断和治疗的新靶点。 DNA dependent protein kinase（DNA-PK）is a key DNA damage repair enzymes of Mammalian cells.Studies have shown that gynecologic oncology,such as cervical and ovarian cancer,expressed DNA dependent protein kinase ubiquitously.Enzyme in these gynecological tumors played an important role in the tumorigenesis and tumor development,and related with tumor clinical stage,radiation sensitivity and prognosis.In recent years,concerning with the structure,function,activity and tumor expression of DNA-PK has been reseached deep.With DNA-PK as the target of the DNA repair inhibitors and cancer chemotherapy-sensitizing drugs have been gradually developed and entered the pre-clinical trials.It is expected to be a new target of cancer diagnosis and treatment.
作者 刘双玥 卢玉波 祝英杰
机构地区 昆明医学院第三附属医院妇瘤科
出处 《医学综述》 2010年第7期1028-1030,共3页 Medical Recapitulate
关键词 DNA依赖蛋白激酶 DNA双链断裂 宫颈癌 卵巢癌 DNA dependent protein kinase； DNA double strand break； Uterine cervix cancer； Ovarian cancer
分类号 R737.3 [医药卫生—肿瘤]
  • 相关文献

参考文献27

  • 1Van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double stranded break connection [ J]. Nat Rev Genet,2001,2 (3) : 196-206.
  • 2Shimura T.Martin MM ,Torres MJ,et al. DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication[ J]. J Mol Biol,2007,367 (3) :665-680.
  • 3Collis SJ,DeWeese TL,Jeggo PA ,et al. The life and death of DNAPK[ J]. Oncogene,2005,24(6) :949-961.
  • 4Dip R,Naegeli H. More than just strand breaks:the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit[J].FASEB J,2005,19(7) :704-715.
  • 5Kuhfittig-Kulle S, Feldmann E, Odersky A, et al. The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV [ J ]. Mutagenesis,2007,22( 3 ) :217-233.
  • 6Sakata K, Someya M, Matsumoto Y, et al. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity[J]. Radiation Medicine ,2007,25 ( 9 ) :433-438.
  • 7He F, Li L, Kim D, et al. Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions [ J ]. Cancer Res, 2007,67 (2) :634-642.
  • 8Sakata K, Yamamoto H, Matsumoto Y ,et al. cDNA analysis of gene expression associated with DNA-dependent protein kinase activity [J]. Int J Oncol,2007,30(2):413-420.
  • 9Um JH,Kwon JK, Kang CD,et al. Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epiderolal growth factor receptor blockade[ J ]. J Pharmacol Exp Ther,2004,311 ( 3 ) : 1062-1070.
  • 10Arlander SJ, Greene BT, Innes CL, et al. DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells[ J]. Cancer Res,2008,68( 1 ) :89-97.

二级参考文献33

  • 1余子建,隋建丽,丁映钦,曹珍山,周平坤,吴德昌.肝胆肿瘤组织中DNA依赖蛋白激酶的表达及意义[J].中华肝脏病杂志,2004,12(11):652-655. 被引量：9
  • 2邵翠杰,夏云飞,史泓浏,张俊英,贺玉香,陈忠平.胶质瘤DNA依赖性蛋白激酶活性与化疗药物敏感性的关系[J].中华肿瘤杂志,2006,28(5):342-344. 被引量：4
  • 3Renu Tuteja, Narendra Tuteja. Critical Reviews in Biochemistry and Molecular Biology, 2000, 35 ( 1 ) : 1.
  • 4Sylvie M, Catherine M, Lionel Met al. Critical Reviews in Biochemistry and Molecular Biology [ J] . J Mol Biol, 2004, 337:503.
  • 5Kim SH, Kim D. Ham JS et al. Ku autoantigen affects the susceptibility to anticancer druge [J] .Cancer Res , 1999 Aug 15, 59 (16): 4012.
  • 6Basilr. Simonab, Abdelmoneme et al. Decrease expression of DNA dependent protein kinase, a DNA repai protein, during human colon carcinogens [J] .CancerRes, 2001, 61 (1): 8381.
  • 7高天祥 田竟生.医学分子生物学[M].北京:科学出版社,2000年1月.212-213.
  • 8Van Gent D C,Hoeijmakers J H,Kanaar R.Chromosomal stability and the DNA double-stranded break connection[J].Nat Rev Genet,2001,2(3):196-206.
  • 9Collis S J,Swartz M J,Nelson W G,et al.Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors[J].Cancer Res,2003,63(7):1550-1554.
  • 10Collis S J,DeWeese T L,Jeggo P A,et al.The life and death of DNA-PK[J].Oncogene,2005,24(6):949-961.

共引文献28

医学综述
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部