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DNA甲基化与宫颈癌的发生及诊治 被引量：2

DNA methylation in cervical carcinogenisis, diagosis and treatment
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摘要 DNA甲基化是表观遗传学的一种常见过程，也是肿瘤相关基因失活的第3种机制，在宫颈癌的发生发展过程中至关重要。研究发现p16、FHIT、IGSF、DAPK1等基因甲基化与宫颈癌的发生发展有关，有望挑选出甲基化的肿瘤标记物，应用到宫颈癌的早期诊断中。对宫颈癌相关基因甲基化的深入研究及宫颈癌的治疗提供新的靶点。 DNA methylation is a common process of epigeneties, and also is the third mechanism of tumor related gene inactivation. It plays an important role in the development of cervical cancer. Studies show that methylation of p16, FHIT, IGSF and DAPK1 have relationship with cervical cancer,thus they may be a biomarker for the early diagnosis of cervical cancer. Meanwhile, advanced study of cervical cancer related gene methylation provides a new target point for treatment.
作者 曾文杰(综述) 叶枫(综述) 吕卫国(审校) 谢幸(审校)
机构地区 浙江大学医学院附属妇产科医院中心实验室
出处 《国际肿瘤学杂志》 CAS 2010年第1期69-72,共4页 Journal of International Oncology
关键词 宫颈肿瘤 DNA甲基化 Uterine cervical neoplasms DNA methylation
分类号 R730.231 [医药卫生—肿瘤]
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共引文献12

同被引文献43

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国际肿瘤学杂志
2010年 第1期

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