摘要
目的:探讨中药三乌芍蝎汤治疗类风湿性关节炎(RA)外周血细胞因子(CK)的变化。方法:随机选择RA病人63例,其中治疗组41例以三乌芍蝎汤1剂/每天,分2次口服。对照组22例,予雷公藤多苷20 mg/次,每天3次;2组均连续服用60 d。同时观察药物对患者外周血细胞因子IL-6,TNF-α,IL-4,IL-10的影响。结果:临床疗效、实验室指标治疗组明显高于对照(P<0.01,P<0.05);治疗组外周血4种细胞因子治疗前后自身比较,均有显著性意义(P<0.05,P<0.01)。与对照组比,治疗后IL-4,IL-10明显上调,有非常显著性意义(P<0.01)。结论:三乌芍蝎汤治疗RA,能调节外周血异常细胞因子,明显改善病人临床症状和实验室指标。
Objective： To investigate the therapeutic effects of Sanwushaoxie decoction on alternations of serum cytokines in patients with rheumatoid arthritis （RA）. Method： Sixty-three （63） RA patients were selected and randomly divided into 2 groups, with the treatment group administered with Sanwushaoxie decoction, one prescription, 2 times a day, while patients in the control group were given Common Threewingnut Root polyglycoside 20 mg a time, 3 times a day. The treatment was lasted for 60 days. Serum concentrations of IL-6, TNF-α IL-4, IL-10 were observed during the treatment. Result： The clinical effecacy and the experimental indexes were significantly improved in the treatment group than those did in the control group （P 〈 0. 01, P 〈 0. 05 ）. There were significant differences of serum levels of 4 cytokines within the treatment group before and after the treatment （P 〈 0. 01, P 〈 0. 05 ）. The seruin levels of IL-4, IL-10 were significantly increased in treatment group compared with those did in the control group （ P 〈 0.01 ）. Conclusion： Sanwushaoxie decoction is an effective agent in regulating cytokines, improving symptoms and experimental indexes in patients with RA.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第6期790-793,共4页
China Journal of Chinese Materia Medica
