摘要
目的探讨肺耐药蛋白基因(LRP)在非小细胞肺癌(NSCLC)中的表达与化疗疗效之间的关系。方法采用免疫组织化学S-P法对47例NSCLC经气管镜活检组织进行LRP表达水平的检测;采用TP方案化疗:紫杉醇脂质体135mg/m2,d1、d8,顺铂80mg/m2,d1,3周为1周期,化疗2周期后评价疗效。结果NSCLC中LRP的表达阳性率为61.70%,在肺腺癌和肺鳞癌中的表达阳性率分别为76.92%和42.86%(P<0.05),LRP表达水平与TNM分期无关(P>0.05)。TP方案化疗2个周期后总有效率为42.55%,其中LRP表达阳性和阴性的有效率分别为27.59%和66.67%(P<0.01)。结论LRP在NSCLC中存在不同程度的表达,其表达在肺腺癌和肺鳞癌之间有差异,并与TP方案化疗的近期疗效相关。
Objective To investigate the relationship between the expression level of lung cancer resistance protein（LRP） and the clinical effects on non-small cell lung cancer（NSCLC） tissues by bronchoscopy biopsy.Methods The expression of LRP was detected in 47 cases of NSCLC tissues through bronchoscopy biopsy or lymphaden biopsy tissues by streptavidin-biotin-peroxidase（S-P） immunohistochemistry technique,and observed the relationship between the expression level of LRP and their clinical effects after two cycles＇ chemiotherapy treated by TP regimen.Results The positive expression rates of LRP on NSCLC was 61.70%.The positive expression positive rates of LRP in the adenocarcinoma and squamous carcinoma were 76.92% and 42.86% respectively.There was statistic difference in LRP expression compared with adenocarcinoma and squamous carcinoma（P〈0.05）.No significance of difference was observed in LRP positive expression rates in different TNM staging of lung cancer（P〉0.05）.The total clinical effective rates was 42.55% after two cycles chemiotherapy treated by TP regimen and the clinical effective rates were 27.59% and 66.67% respectively between the positive expression of LRP and negative expression of LRP,and there was statistic difference in those two groups（P〈0.01）.Conclusion There was different degree expression of LRP in NSCLC and also statistic difference in LRP expression level compared with adenocarcinoma and squamous carcinoma,as well as in clinical effects after treated with TP regimen.There was statistic difference between the negative expression of LRP and positive expression of LRP.
出处
《临床肿瘤学杂志》
CAS
2010年第3期215-217,共3页
Chinese Clinical Oncology
基金
河北省重点发展学科资助项目(20042761595)
