摘要
目的研究麦芪口服液对D-半乳糖所致衰老模型大鼠的抗氧化作用。方法采用腹腔注射D-半乳糖的方法,制作衰老动物模型。60只大鼠随机分成正常对照组、模型组、维生素C阳性对照组和高、中、低3个剂量的麦芪口服液组。测定各组大鼠血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量。结果与模型对照组比较,麦芪口服液能明显升高衰老模型大鼠的血清中SOD(P<0.01)和GSH-Px(P<0.05)的活性,减少MDA的含量(P<0.01)。结论麦芪口服液具有抗氧化作用。
OBJECTIVE To investigate the antioxidative effect of Maiqi oral solution（MOS） on aging model rats induced by D-galactose.METHODS Aging rats model was established by administrating D-galactose intraperitoneally.Sixty rats were divided into 6 groups randomly as follows：normal control group,model group,Vit C group,and three different doses of MOS.The activity of SOD,GSH-Px and the level of MDA in blood serum were measured.RESULTS Compared with model group,MOS could significantly improve the activity of SOD and GSH-Px,and markelly decrease the concentration of MDA in blood serum.CONCLUSION MOS has antioxidative effect on aging rats induced by D-galactose.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2010年第3期190-192,共3页
Chinese Journal of Modern Applied Pharmacy
