摘要
目的:根据现有临床研究评价甘草酸二铵治疗药物性肝损害的有效性及安全性。方法:检索1994～2009年中国生物医学文献数据库、中国期刊网数据库,比较甘草酸二铵与其它保肝药物治疗有效率的随机对照试验(RCT)文献,并对RCT进行系统评价。结果:18项RCT,共1644例药物性肝损害患者入选。甘草酸二铵组有效率高于对照组,2组比较差异有统计学意义(P<0.05);在降低丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素等生化指标及药物不良反应等方面,甘草酸二铵组与对照组比较的差异无统计学意义(P≥0.05)。结论:系统评价结果显示,甘草酸二铵比其它保肝药能够更有效的治疗药物性导致的肝功能损害。
OBJECTIVE： To evaluate the efficacy and safety of diammonium glycyrrhizinate in the treatment of drug-induced liver injury according to present clinical studies. METHODS： Retrieved from CBM and the CNKI from 1994 to 2009, literatures about the randomized controlled trials that the effective rate of diammonium glycyrrhizinate was compared with that of other hepatoprotective with drug-induced liver injury and drug-induced liver disease as study subjects. RESULTS： 18 RCTs including 1,644 patients with drag-induced liver injury were enrolled. The effective rate of diammonium glycyrrhizinate group was higher than that of control group, statistical significance was noted in two groups （P〈0.05）. There was no statistical significance between two groups in respect of adverse drug reaction and reduction of biochemical indicators such as ALT, AST and TBIL （P≥0.05）. CONCLUSION： Results of systematic review demonstrate that diammonium glycyrrhizinate has better effect than other hepatoprotective on drug-induced damage of liver function.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第12期1100-1105,共6页
China Pharmacy
关键词
药物性肝损害
甘草酸二铵
系统评价
Drug-induced liver injury
Diammonium glycyrrhizinate
Systematic review
