摘要
为检测重组人肝细胞生长因子（ｒ－ｈＨＧＦ）的保肝作用，本工作观察到ｒ－ｈＨＧＦ降低ＣＣｌ４染毒小鼠血清ＡＬＴ和ＡＳＴ升高的幅度，减轻肝组织受损的程度和防止肝细胞器的破坏，而且，ｒ－ｈＨＧＦ的这种保肝效应所需剂量极小，为ｎｇ级。根据上述资料推测。
To assess the protective effect of recombinant human hepatocyte growth factor ( r hHGF ) on liver, it was found the factor was capable of suppressing elevation of serum alanine transaminase and aspartate transaminase, lessning the severity of the hepatic lession and preventing destruction of the structure of organelle in hepatocyte of mice intoxicated by carbon tetrachloride. The protective action of the r hHGF appears to be a very small dose(ng). Based upon the above mentioned data, it is suggested that r hHGF is a very effective growth factor to protect mice liver against CCL 4 injury.
出处
《中国应用生理学杂志》
CAS
CSCD
1998年第4期339-342,共4页
Chinese Journal of Applied Physiology
基金
国家自然科学基金
辽宁省卫生厅科研基金
关键词
四氯化碳
保护作用
γ-hHGF
肝
recombinant human hepatocyte growth factor(r hHGF)
carbon tetrachloride
protective action
