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阻断JAK/STAT通道对大鼠缺血再灌注心肌细胞凋亡及Bcl-2/Bax表达的影响 被引量：10

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摘要 缺血再灌注损伤是心脏外科手术体外循环中一个常见的病理生理过程，在这个过程中常伴有心肌细胞的死亡。它包括心肌细胞的坏死和心肌细胞的凋亡．其中心肌细胞的凋亡占主要的地位，文献[1]报道缺血再灌注过程中可发生细胞凋亡，细胞凋亡加重再灌注损伤。
作者 梁艳盆 马捷
机构地区 山西医科大学第二医院心胸外科
出处 《中国药物与临床》 CAS 2010年第4期424-426,共3页 Chinese Remedies & Clinics
关键词 缺血再灌注损伤 心肌细胞凋亡 BAX表达 Bcl-2 T通道 大鼠 病理生理过程 心脏外科手术
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献10

  • 1Holleyman CR,Larson DF.Apoptosis in the ischemic reperfused myocardium.Perfusion,2001,16(6):491-502.
  • 2Nakamura M,Wang NP,Zhao ZQ,et al.Preconditioning decreases Bax expression,PMN accumulation and apoptosis inreperfused rat heart.Cardiovasc Res,2000,45(3):661-670.
  • 3Maulik N,Engelman RM,Rousou JA,et al.Ischemic preconditioning reduces apoptosis by upregulating antideath gene Bcl-2.Circulation,1999,100(19):369-375.
  • 4Stephanou A,Brar BK,Scarabelli TM,et al.Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis.Biol Chem,2000,275(14):10002-10008.
  • 5沈诚,范士志,陈建明,李志平,何勇.JAK/STAT通路对缺血再灌注心肌NF-κB和TNF-α表达的影响[J].中国现代医学杂志,2006,16(7):985-987. 被引量：19
  • 6Omura T,Yoshiyama M,Ishikura F,et al.Myocardial ischemiaactivates the JAK-STAT pathway through angiotensin Ⅱ signaling in vivo myocardium of rats.J Mol Cell Cardiol,2001,33(2):307-316.
  • 7Xuan YT,Guo Y,Han H,et al.An essential role of the JAK-STAT pathway in ischemic preconditioning.Proc Natl Acad Sci USA,2001,98(16):9050-9055.
  • 8Negoro S,Kunisada K,Tone E,et al.Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction.Cardiovasc Res,20002,47(4):797-805.
  • 9Garcia-Dorado D,Rodriquez-Sinovas A,Ruiz-Meana M,et al.The end effectors of preconditioning protection againstmyocardial cell death secondary to ischemia reperfusion.Cardiovasc Res,2006,70(2):274-276.
  • 10Hattori R,Maulik N,Otani H,et al.Role of STAT3 in ischemiapreconditioning.J Mol Cell Cardiol,2001,33(1):1929-1936.

二级参考文献8

  • 1ALLER MA,ARIAS JL,NAVA MP,et al.osttraumaric inflammarion is a complex response based on the pathological expression of the nervous,immune,and endocrine functional systems[J].Exp Biol Med (Maywood).2004,229(2):170-181.
  • 2MARRERO MB,VENEMA V J,HE H,et al.Inhibition by the JAK/STAT pathway of IFNgamma-and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cell[J].Biochem Biophys Res Commun,1998,252(2):508-512.
  • 3WANG M,BAKER L,TSAI BM,et al.Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury[J].Am J Physiol Endocrinol Metab.2005,288(2):E321-326.
  • 4PATHMANATHAN S,KRISHNA MT,BLOMBERG A,et al.Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5,IL-10,IL-13,and ICAM-1 in the bronchial epithelium of healthy human airways[J].Occup Environ Med.2003,60(11):892-896.
  • 5JEE SH,CHU CY,CHIU HC,et al.Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways[J].J Invest Dermatol.2004,123(6):1169-1175.
  • 6YOKOGAMI K,WAKISAKA S,AVRUCH J,et al.Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target Mtor[J].Curr Biol.2000,10(1):47-50.
  • 7HELD TK,WEIHUA X,YUAN L,et al.Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms,at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1[J] Infect Immun.1999,67(1):206-212.
  • 8杨君佑,杨浩,戴忠,李莉芳.芹菜水提物对心肌缺血再灌注损伤的保护作用(英文)[J].中国现代医学杂志,2004,14(9):40-41. 被引量：12

共引文献18

同被引文献132

引证文献10

二级引证文献55

中国药物与临床
2010年 第4期

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