摘要
目的观察三七通舒胶囊治疗脑梗塞患者前后的血液流变学指标、血脂及纤维蛋白原变化。并与同期非脑血管患者的血液流变学指标、血脂及纤维蛋白原指标比较,分析以上指标在脑梗塞防治中的临床意义。方法按入院时间纳入120例脑梗塞住院患者(男69例、女51例),在发病24～48h内给予三七通舒胶囊治疗,疗程3个月,观察治疗前后血流变、血脂,纤维蛋白原指标变化。同期选择平均年龄一致的86例非脑血管疾病的患者(男51例、女35例),比较两组在治疗前的血液流变学指标、血脂及纤维蛋白原水平。结果经过3个月三七通舒胶囊治疗后,120例脑梗塞患者的血液流变学指标、TC、TG和纤维蛋白原水平明显降低,治疗前后的差异具有统计学意义(P<0.05)。而脑梗塞患者与非脑血管疾病患者相比,全血粘度,血浆粘度明显增高,红细胞压积增加,红细胞刚性指数较大;而TC、TG和纤维蛋白原水平明显增高。结论早期使用三七通舒胶囊治疗脑梗塞患者能有效的调节血液粘度,降低血脂水平,降低纤维蛋白原浓度,改善微循环,促进血栓溶解,改善患者预后情况。对老年、脑梗塞高危人群进行血液流变学指标、血脂及纤维蛋白原指标筛查,对预防脑梗塞发生,降低发病率有积极意义。
Objective To evaluate the effects of pseudo-ginseng Tongshu capsule on changes of bloodstream, blood plasma lipid and Fibrin of patients with Brain Infarction.
Methods The patients with Brain Infarction were randomly selected, among whom 120 received pseudo-ginseng Tongshu capsule for 3 month and 86 received the routine therapy. Before and after the treatment, change of bloodstream, blood plasma lipid and Fibrin were tested.
Results A total of 120 patients were included in the treatment group and 86 in the control group. In the 3rd month, the level of total cholesterol （TC） and Fibrinogen was decreased significantly in the patients with Brain Infarction （P〈0.05）.
Conclusion The level of blood plasma lipid and Fibrinogen is decreased significantly in the patients with Brain Infarction who accept pseudoginseng Tongshu capsule.
出处
《中国循证医学杂志》
CSCD
2010年第4期499-500,共2页
Chinese Journal of Evidence-based Medicine
