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氯胺酮在体外循环中对核因子-κB及其他炎性介质表达的影响 被引量：1

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摘要 目的观察氯胺酮在体外循环(CPB)中对核因子-κB(NF-κB)活性表达的影响及与TNF-α、IL-1活性表达的相关性。方法选择2008年全年CPB心内直视下瓣膜置换术手术患者24例,随机分成对照组和氯胺酮组,每组12例,氯胺酮组在诱导后和CPB流转开始前分别缓慢静脉滴注氯胺酮1 mg/kg,对照组静脉滴注同等容量的生理盐水,通过ELISA法-双抗体夹心法测定麻醉诱导后CPB前(T1)、CPB后30 min(T2)、CPB后1 h(T3)、CPB后4 h(T4)、手术结束(T5)、手术结束后24 h(T6)的NF-κB及TNF-α、IL-1的表达。结果两组患者在T3、T4时NF-κB及TNF-α、IL-1的表达较T1有明显增高,但氯胺酮组活性表达较对照组显著降低。结论氯胺酮在CPB中应用能够抑制NF-κB及其他炎性介质的活性表达。
作者 陈翀 陈钢
机构地区 浙江大学医学院附属第二医院麻醉科
出处 《社区医学杂志》 2010年第7期8-9,共2页 Journal Of Community Medicine
关键词 氯胺酮 体外循环 核因子-ΚB 炎性介质
分类号 R645.1 [医药卫生—外科学]
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参考文献7

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共引文献12

同被引文献12

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社区医学杂志
2010年 第7期

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