摘要
目的了解双相障碍住院患者的肥胖与代谢相关障碍,并与精神分裂症住院患者作一比较。方法对上海市精神卫生中心分部2008年7月住院期间的双相障碍患者作调查,测定其身高、体重及各代谢指标,用世界糖尿病联盟全球统一标准(IDF)定义代谢综合征及中心性肥胖。随机选取同期住院的两个病房的精神分裂症患者作为比较。结果共入组双相障碍患者30例,精神分裂症160例。代谢综合征的患病率均较高,肥胖与代谢相关指标如血压、血糖、血脂方面,双相障碍患者与精神分裂症患者的患病率均无统计学差异(P>0.05)。二组的超重、高甘油三酯、低HDL及中心性肥胖的比例均明显增高(P>0.05)。结论在住院的双相障碍及精神分裂症患者中同样存在较多代谢相关障碍,需要政策层面的关注。
Objective To estimate the prevalence of metabolic syndrome （MS） in inpatients with bipolar disorder （BD） ,compared with schizophrenic inpatients under naturalistic conditions. Methods Thirty inpatients with bipolar disorder （BD） and 160 schizophrenic inpatients treated in Shanghai Mental Health Center Branch were investigated. Metabolic indexes were measured. The criteria of MS based on the consensus definition released by the International Diabetes Federation. Results The prevalence of MS was significantly higher in BD and schizophrenia,with no significant difference between two groups（ P = 0.319）. All MS components were higher in the BD and schizophrenia group, particularly BMI 〉23 kg/m^2（80.0% VS. 69.4% ,P =0.279）, high triglyceride levels （63.3% VS. 47.5% P =0. 163）, and low HDL cholesterol levels （73.5 % VS. 56.3% ,P = 0. 106）. Furthermore, patients with BD and schizophrenia showed a significantly higher frequency of central obesity （80.0% VS. 85.0% ,P = 0.476）. Conclusion Compared with schizophrenic inpatients, the prevalence of MS in inpatients with BD is equally high, particularly in the components of overweight, high triglyeeride levels, low HDL cholesterol levels and central obesity. These findings strongly support the development of health policies addressing this problem in patients with BD as well as in schizophrenic patients.
出处
《精神医学杂志》
2010年第2期90-93,共4页
Journal of Psychiatry
