摘要
目的探讨γ型含铜、含消炎痛（γＣｕＩ）宫内节育器（ＩＵＤ）对子宫内膜螺旋动脉形态的影响，及其防治出血副反应的机理。方法取９例放置γＣｕＩＩＵＤ妇女（γＣｕＩ组）、１０例放置ＴＣｕ２２０ＣＩＵＤ妇女（ＴＣｕ２２０Ｃ组）及１０例放置前妇女（放置前组）的晚泌期子宫内膜，连续切片，ＨＥ染色后，光镜下对螺旋动脉行形态计量学分析。结果ＴＣｕ２２０Ｃ组子宫内膜致密层和海绵层螺旋动脉的平均截面积（Ａｒｅａ）、最大直径（Ｄｍａｘ）和最小直径（Ｄｍｉｎ）显著增加（Ｐ＜０．０５）。γＣｕＩ组海绵层螺旋动脉Ａｒｅａ和Ｄｍａｘ与放置前组差异无显著性（Ｐ＞０．０５），致密层Ａｒｅａ和Ｄｍａｘ增加，但程度均小于ＴＣｕ２２０Ｃ组（Ｐ＜０．０５），各层螺旋动脉Ｄｍｉｎ的增加较ＴＣｕ２２０Ｃ组更明显（Ｐ＜０．０５）。结论γＣｕＩＩＵＤ与ＴＣｕ２２０ＣＩＵＤ相比，较少影响子宫内膜功能层螺旋动脉的形态，可能与减少出血性副反应的机理有关。
Objective To investigate the morphologic changes of endometrial spiral arterioles and its relationship with bleeding pattern after insertion of γ shape copper indomethacin medicated (γCuI) and T shape copper (TCu 220C) intrauterine devices (IUD). Methods Endometrium specimens of late secretory phase were obtained from fertile age women: 10 from preinsertion, 10 obtained after insertion of TCu 220C IUD, and 9 obtained after insertion of γCuI IUD. Samples were sectioned serially and morphometric analysis of endometrial spiral arterioles was performed under light microscope. Results The average cross section area (Area), maximum diameter (Dmax) and minimum diameter (Dmin) of spiral arterioles in both spongeous and dense layers of endometrium increased significantly after insertion of TCu 220C IUD. After insertion of γCuI IUD, the Area and Dmax increased in dense layer only, though less obviously than that occurred in TCu 220C group. However, the Dmin increased more obviously in both spongeous and dense layers than after insertion of TCu 220C IUD, implying that the shape of spiral arterioles was more regular in γCuI group. Conclusion γCuI IUD has less effects on the morphological changes of endometrial spiral arterioles, and this may relate to its indomethacin contained which causes less bleeding.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1998年第4期232-234,I006,共3页
Chinese Journal of Obstetrics and Gynecology
基金
国家八五攻关项目基金
关键词
子宫内膜
宫内避孕器
铜
含药
螺旋动脉
Endometrium
Intrauterine devices
copper
Intrauterine devices
medicated
