摘要
目的:研究维生素D受体基因多态性在中国蒙古族人群中的分布情况,并探讨维生素D受体Fok1基因多态性与蒙古族2型糖尿病视网膜病变的相关性。方法:采用聚合酶链-限制性片断长度多态性检测方法,比较蒙古族正常人群和2型糖尿病视网膜病变患者之间维生素D受体基因多态性等位基因频率和基因型频率的差异。结果:维生素D受体基因Fok1酶切位点各基因型在2型糖尿病视网膜病变组和正常对照组中的分布差异具有统计学意义。两组间等位基因频率总体分布差异有统计学意义。2型糖尿病视网膜病变组等位基因f和基因型ff频率明显高于正常对照组。结论:中国蒙古族人群中维生素D受体基因多态性与2型糖尿病视网膜病变相关联,等位基因f是蒙古族2型糖尿病视网膜病变的易感基因。
Objective：To explore the relationship between DNA polymorphism of human vitamin D receptor（VDR） gene and type 2 diabetic retinopathy in mongolian people.Method：By restriction fragment length polymorphism analysis,the alleles frequencies and genotype frequencies of VDR gene were compared with normal subjects and type 2 diabetic retinopathy in mongolian people.Results： The prevalence of VDR gene genotype frequencies and alleles frequencies in type 2 diabetic retinopathy were significantly different with that in control subjects.The alleles f and genotype ff were more common in type 2 diabetic retinopathy than in control subjects.Conclution： Polymorphism of VDR gene is associated with type 2 diabetic retinopathy in mongolian people.Alleles f may be a susceptible gene contributing to the development of type 2 diabetic retinopathy in mongolian people.
出处
《内蒙古医学杂志》
2010年第3期271-274,共4页
Inner Mongolia Medical Journal
