摘要
目的探讨帕金森病（PD）非运动症状的发生、不同运动症状分级（H—Y）时的分布及其影响因素。方法用统-PD评分量表Ⅲ和V（UPDRS-Ⅲ、UPDRS—V）、PD非运动症状问卷（NMSQuest）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、帕金森病睡眠量表（PDSS）及简易智能量表（MMSE）评分对169例PD患者进行评估，并与102名正常组对照。结果99．41％的PD患者存在非运动症状；76．33％的患者存在抑郁症状，80．47％的患者存在焦虑症状；帕金森病患者的焦虑、抑郁、睡眠及非运动症状明显多于对照组；不同Hoehn和Yahr（H—Y）分级间患者的非运动症状表现及严重度差异明显；焦虑、H—Y分级、性别、PDSS及MMSE得分进入回归方程。结论帕金森病患者非运动症状明显，且在不同运动症状分级间表现及严重程度中具有一定特点。
Objective To survey the prevalence,distribution of non-motor symptoms （NMS） in different H-Y stage of Parkinson diseases（PD） and some correlative factors of NMS. Methods 169 patients with PD and 102 controls were involved in the survey. Parkinson diseases rating scale Ⅲ （UPDRS-Ⅲ） and V （UPDRS-V）, Non-Motor Symptoms Questionnaire for Parkinson ＇ s disease （ NMSQuest ） , Hamihon depression scale （HAMD） , Hamilton Anxiety Scale （HAMA）,Parkinson＇ s Disease Sleep Scale （PDSS） and Mini-Mental State Examination （MMSE） were used to assess motor and non-motor symptoms. Results Most patients had non-motor symptoms （99.41%） ,ineluding depressive symptoms （76.33%） and anxious symptoms （80.47%）. The scores of HAMA, HAMD,PDSS and NMSQuest of patients were significant different from those of the controls. There were significant different between the different H-Y stages on the distribution and severity of NMS. The HAMA,the H-Y stage, PDSS,gender and MMSE had entered the regression equation. Conclusion NMS in PD are common and fi＇equent. There are different elirfical characteristics on the distribution and severity of NMS between the different H-Y stages.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2010年第4期331-333,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
基金项目：江苏省中医药科技项目（LB09088）
南京市科技计划项目（200905016）
关键词
帕金森病
非运动症状
量表
Parkinson＇s disease
Non-motor symptom
Scales
