摘要
目的了解青浦区1999年～2008年新登记肺结核患者的原发耐药情况。方法采用绝对浓度法对新发初治肺结核患者痰标本培养菌株进行链霉素(S)、异烟肼(H)、利福平(R)和乙胺丁醇(E)4种抗结核药物的耐药性测定,统计分析原发耐药情况。结果原发总耐药率由1999年～2000年的9.2%上升至2007年～2008年的15.5%;S、H、E的耐药率由1999年的5.0%、7.1%、2.8%上升至2008年的12.1%、13.8%、3.4%;R的耐药率由1999年的5.0%下降至2007年～2008年的4.3%;原发耐多药率(MDR-TB)平均为4.5%。2药、3药的耐药率分别由1999年的2.1%、0%上升至2008年的6.0%、1.8%。1药、4药的耐药率基本在同一水平。结论青浦区肺结核患者临床分离株原发耐药性成上升趋势,耐多药菌株仍占一定比例。
Objective To illustrate the primary drug-resistance of new register of mycobacterium tuberculosis（MTB） in Qingpu 1999 - 2008. Methods Absolute concentration method was used for the detection of drug sensitivity of four kinds of anti-tuberculosis agents such as IMH, SM, KFP, EMB. The circumstance of primm＇y drug resistance of MTB was analyzed. Results The rate of total primary drug resistance to SM,IMH and EMB were 5.0% ,7.1% and 2.8%, respectively in 1999 - 2000 and increase to 12. 1%, 13.8% and 3.4% in 2007 - 2008, while the rate of primary drug resistance to RIP was 5.0% in 1999- 2000 and decreased to 4.3 % in 2007- 2008, the average rate of primary MDR-TB was 4. 5%. The rale of drug resistance to two kinds of drug and three kinds of drug were 2. 1% and 0% respectively in 1999 - 2000, and increased to 6. 3 %, and 1.8% in 2007 - 2008. Another two kinds were at the same level. Conclusion The primary drug resistance of M tuberculosis in Qingpu 1999 - 2008 is in a trend of increase and multi-drug resistance is still seriously existed.
出处
《临床肺科杂志》
2010年第6期810-811,共2页
Journal of Clinical Pulmonary Medicine
