摘要
目的比较顺铂腹腔灌注联合多西紫杉醇静脉化疗双途径治疗与顺铂联合多西紫杉醇单纯静脉化疗治疗晚期卵巢癌的临床疗效、不良反应。方法Ⅲ~Ⅳ期初治卵巢癌患者55例,随机分为治疗组（IP＋IV组：顺铂腹腔灌注联合多西紫杉醇静脉化疗双途径治疗）28例,对照组（IV组：顺铂联合多西紫杉醇单纯静脉化疗）27例。结果治疗组有效率82.14%（23/28）,对照组有效率70.37%（19/27）,两组比较,差异有显著性（P〈0.05）。全身毒性反应主要为消化道反应、肾毒性、血液学毒性和神经毒性,全身毒性反应治疗组较对照组略低;而局部毒性主要有腹痛、化学性腹膜炎和腹腔粘连,局部毒性反应治疗组较对照组略高。组间比较差异无显著性（P〉0.05）。结论治疗组较对照组治疗晚期卵巢癌疗效更高,毒性反应可以耐受,腹腔化疗应用于晚期卵巢癌是一种合理而可行的治疗模式。
Objective To observe the effect,toxicity of advanced ovarian cancer,treated with IP ＋IV and IV regimen. Methods 55 cases of advanced ovarian cancer（stage Ⅲ-IV） were treated,in which 28 patients received IP＋IV regimen（CDDP intraperitoneal ＋DOC iv） and 27 patients received IV regimen（CDDP iv ＋DOC iv）. Results In IP＋IV group,the response rate was 82.14%（23/28）.In IV group the respose rate was 70.37%（19/27）.The efficacy was statistically significant（P〈0.05）.The main systematic toxicity were gastrointestinal reaction,nephrotoxicity,myelosuppression and neurotoxicity.The systematic toxicity of IV is a little more than IP＋IV,but the local toxicity is on the contrary.The main local toxicity were abdominalgia,abdominatis and abdominal adhesion.The efficacy was not statistically significant（P〉0.05）.Conclusion IP＋IV regimen are more effective than IV regime to patients with advanced ovarian cancer.The toxicity can be tolerated.Intraperitoneal chemtherapy can be applied to advanced ovarian cancer.
出处
《南华大学学报（医学版）》
2010年第1期120-122,共3页
Journal of Nanhua University(Medical Edition)
关键词
晚期卵巢癌
腹腔灌注化疗
静脉化疗
多西紫杉醇
顺铂
advanced ovarian cancer
intraperitoneal chemotherapy
intravenous chemtherapy
docetaxel
cisplatin
