摘要
目的:评估甲地孕酮治疗肿瘤化疗引起的呕吐和白细胞减少的疗效。方法:100例肿瘤病人随机分成研究组(50例)和对照组(50例),对照组方案:化疗前半小时静脉推注昂丹司琼8mg,地榆升白片,4片/次,每日3次,全程口服;研究组止吐方案:昂丹司琼和地榆升白片用法同对照组,每例患者自化疗第一天早晨口服甲地孕酮160mg,连用10天。3周为1周期。结果:研究组和对照组急性呕吐发生率分别是40.00%和62.00%(P<0.05),迟发性呕吐发生率分别是30.00%和58.0%(P<0.01),白细胞减少的比率分别是50.00%和72.00%,有显著性差异(P<0.05)。Ⅲ度以上发生率分别是12.00%和26.00%(P>0.05)。结论:在肿瘤化疗中,联合应用甲地孕酮防治呕吐疗效较好,尤其对迟发性呕吐效果更加明显,同时可明显缓解白细胞减少。
Objective：To evaluate the efficacy against vomit and leucopenia duo to chemotherapy for patients with megestrol acetate （MA）. Methods： Total of 100 patients was randomized into control group （50 cases） and study group （50 cases）, control group： ondansetron 8mg intravenous injection half an hour before chemotherapy, Diyush- engbaipian 4 tablets per time tid. Study group ： the administration of ondansetron and Diyushengbaipian was the same as control group, and MA 160mg qd × 10 day from the morning of dayl of chemotherapy, three weeks per cycles. Re- suits： The rates of acute vomitting in study group and control group were respectively 35.00% and 60.00% （ P 〈 0.05）, the rates of delayed vomitting were respectively 27.50% and 57.50% （ P 〈 0.01 ）. The rates of leuco- penia （ I - Ⅳ ） were respectively 50.00% and 72.00% （ P 〈 0.01 ）, the rates of leucopenia （ Ⅲ - Ⅳ ） wei, e re- spectively 12.00% and 26.00% （P 〉 0.05 ）. Conclusion： Megestrol acetate can prevent vomitting significantly, es- pecially for delayed vomitting, and can relief leucopenia significantly.
出处
《现代肿瘤医学》
CAS
2010年第5期1000-1002,共3页
Journal of Modern Oncology
关键词
甲地孕酮
化疗
呕吐
白细胞减少
megestrol acetate
chemotherapy
vomit
leucopenia
