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ERCC1、BRCA1在非小细胞肺癌的表达与顺铂耐药的研究进展 被引量：14

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摘要 顺铂广泛应用于非小细胞肺癌(non-small cell lung cancer,NSCLC)的化疗,但耐药性的产生严重影响其疗效。顺铂耐药的机制尚不十分清楚。目前普遍认为错配切除修复蛋白1(excision repaircross completion gene1,ERCC1)及乳腺癌易感基因1(breast cancer susceptibility gene1,BRCA1)的表达与顺铂耐药性相关。抑制ERCC1及BRCA1的表达可克服顺铂耐药性,提高治疗效果。
作者 董云 李志革
机构地区 广西医科大学附属肿瘤医院化疗二科
出处 《现代肿瘤医学》 CAS 2010年第5期1037-1041,共5页 Journal of Modern Oncology
基金 广西自然科学基金资助项目(编号:桂科自0832233)
关键词 ERCC1 BRCA1 耐药 肺癌
分类号 R734.2 [医药卫生—肿瘤]
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参考文献34

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二级参考文献65

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二级引证文献48

现代肿瘤医学
2010年 第5期

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