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IL-18及IgE在异位性皮炎的表达及其与EASI的相关性 被引量：12

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摘要 分析异位性皮炎(AD)皮损内白细胞介素18(IL-18)的表达和血清IgE水平与湿疹面积及严重度指数(EASI)的相关性。采用荧光定量聚合酶链反应法测定22例AD患者皮损内IL-18 mRNA的表达,采用酶联免疫吸附试验检测血清中IgE水平,20名正常皮肤作对照。采用EASI评分评估患者病情,分析与IL-18 mRNA表达和IgE水平的相关性。AD患者皮损内IL-18 mRNA及血清中IgE表达明显高于对照组(均P<0.01);AD患者血清中IL-18 mRNA的表达和IgE水平与EASI评分呈显著的正相关(分别为P<0.0001和P=0.0369)。IL-18及IgE的过度表达可能参与了AD的发病,IL-18或IgE水平可以作为判断AD患者病情严重程度的指标之一。
作者 李常兴 李雪梅 韩春雷 马泽粦 张锡宝
机构地区 广东省东莞市慢性病防治院 广州市皮肤病防治所
出处 《中国麻风皮肤病杂志》 2010年第4期252-253,共2页 China Journal of Leprosy and Skin Diseases
关键词 异位性皮炎 免疫球蛋白E 白细胞介素18 湿疹面积及严重度指数
分类号 R758.2 [医药卫生—皮肤病学与性病学]
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参考文献9

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二级参考文献12

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共引文献19

同被引文献78

引证文献12

二级引证文献44

中国麻风皮肤病杂志
2010年 第4期

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