摘要
肝豆状核变性即Wilson病(WD),是少数几种可治的神经遗传性疾病之一。目前国内外常用的驱铜药物有青霉胺、曲恩汀、锌制剂和四硫钼酸盐。本文作者结合自己多年丰富的临床经验提出,青霉胺与曲恩汀并不适用神经型WD患者的初始治疗,而锌制剂可用于WD患者的初始以及终身维持治疗。对WD患者的低铜饮食笔者也提出了自己的观点。
Hepatolenticular degeneration, also called Wilson＇s disease （WD）, is one of the curable genetic diseases in the field of neurology. Drugs commonly used in clinic include D-penicillamine, trientine, zinc and tetrathiomolybdate. The author of this review indicates that D-penicillamine and trientine are not proper to the WD patients with neurological symptoms in initial treatment, and zinc may be good in initial treatment and life-long maintenance. This review also describes the new opinion about low copper diet for WD patients.
出处
《世界临床药物》
CAS
2010年第5期257-260,共4页
World Clinical Drug
关键词
肝豆状核变性
青霉胺
曲恩汀
锌制剂
四硫钼酸盐
低铜饮食
hepatolenticular degeneration
D-penicillamine
trientine
zinc
tetrathiomolybdate
low copper diet
