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老年高血压患者动态脉压和脉压指数与估测肾小球滤过率的相关性 被引量:10

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摘要 目的评价老年高血压患者动态脉压(PP)及脉压指数(PPI)与估测肾小球滤过率(eGFR)的相关性,探讨PP及PPI在老年高血压患者肾功能受损中的作用。方法218例行24h动态血压检查的老年高血压患者,根据PP(≤55mmHg或>55mmHg)和PPI(≤0.45或>0.45)进行分组,比较各组间eGFR的差异,以及与PP、PPI的相关性。结果与PP≤55mmHg组或PPI≤0.45组比较,在PP>55mmHg或PPI>0.45组中eGFR值明显降低(P<0.01)。Pearson相关分析显示,eGFR与PP及PPI呈显著负相关;控制年龄、平均收缩压、平均舒张压、血肌酐水平等因素后,偏相关分析显示,eGFR仍与PP(r=-0.230,P<0.01)及PPI(r=-0.250,P<0.01)相关。多元逐步回归分析显示eGFR与肌酐水平、PPI及PP独立相关,标准化偏回归系数分别为-0.827、-0.177和-0.170,P<0.001。结论老年高血压患者随着PP及PPI水平的升高,eGFR值明显降低,PP和PPI是老年高血压患者肾功能受损的独立危险因素。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第8期1052-1054,共3页 Chinese Journal of Gerontology
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