摘要
目的研究中药细辛的遗传毒性,为临床用药提供理论依据。方法应用小鼠骨髓嗜多染红细胞微核实验和精子畸形实验,观察细辛水煎液在小鼠体内对雄性体细胞和生殖细胞遗传物质的损伤,通过微核率和畸形率评价细辛对雄性小鼠的遗传毒性作用。结果细辛水煎液能明显诱发小鼠骨髓嗜多染红细胞微核和小鼠精子畸形,具有致突变作用。结论中药细辛作为临床常用的中草药,临床应用时需考虑其遗传毒性。
Objective To study the genetic toxicity of Asarum heterotropoides Fr.Schmidt.Methods Observation whether the Decoction of Asarum heterotropoides Fr.Schmidt.Var.mandshuricum Kitag.will induce genetic material injury in male mice＇ somatic and germ cells or not by mouse polychromatic erythrocytes micronucleus test and mouse sperm abnormality test,indicated the genetic toxicity of Asarum heterotropoides Fr.Schmidt.by micronucleus rate and the malformation rate and deformity constituent ratio.Results Asarum heterotropoides Fr.Schmidt.could significantly induce mouse polychromatic ery-throcytes micronuclei and sperm abnormalities,it has mutagenic effect.Conclusion Asarum heterotropoides Fr.Schmidt.as a clinical efficacy of commonly used Chinese herbal medicine has a variety of genetic toxicity,clinical applications need to consider their genetic toxicity.
出处
《中国药物警戒》
2010年第5期262-264,共3页
Chinese Journal of Pharmacovigilance
基金
吉林省中医药管理局项目(08SYS-070)
关键词
细辛
环磷酰胺
精子畸形
微核
Asarum heterotropoides Fr.Schmidt
cyclophosphamide
sperm abnormality
micronuclei
