期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ghrelin与动脉粥样硬化 被引量：8

Ghrelin and Atherosclerosis
在线阅读 下载PDF
导出
摘要 Ghrelin是近年来发现的一种促进生长激素分泌的多肽,是生长激素促分泌物受体的内源性配体。研究发现,ghrelin除了具有增加摄食及调节能量代谢的作用外,还具有降低血压、对抗炎症反应、保护血管内皮细胞等多种生物学效应,提示其在心血管疾病尤其是在动脉粥样硬化方面具有潜在的治疗效应。 Ghrelin,a recently discovered peptide hormone with strong growth hormone releasing activity,is an endogenous ligand of the growth hormone secretagogue receptor.At present,researchers have found that ghrelin is able to increase food intake and regulate energy metabolism.In addition,ghrelin is thought to lower blood pressure,fight inflammation,and protect vascular endothelial cells.This suggests that ghrelin has a potential therapeutic effect against atherosclerosis.
作者 王丽 陈庆伟
机构地区 重庆医科大学第二临床学院老年病科
出处 《心血管病学进展》 CAS 2010年第3期476-478,共3页 Advances in Cardiovascular Diseases
关键词 GHRELIN 动脉粥样硬化 内皮细胞 ghrelin atherosclerosis endothelial cells
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献28

  • 1Iglesias MJ,Pieiro R,Blanco M,et al.Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes[J].Cardiovasc Res,2004,62(3):481-488.
  • 2Kleinz MJ,Maguire JJ,Skepper JN,et al.Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man[J].Cardiovasc Res,2006,69(1):227-235.
  • 3Katugampola SD,Pallikaros Z,Davenport AP,et al.[125I-His(9)] -ghrelin,a novel radioligand for localizing GHS orphan receptors in human and rat tissue:up-regulation of receptors with athersclerosis[J].Br J Pharmacol,2001,134(1):143-149.
  • 4张兴平,陈庆伟.Ghrelin与慢性心力衰竭[J].心血管病学进展,2005,26(6):573-575. 被引量：2
  • 5Dixit VD,Yang H,Cooper-Jenkins A,et al.Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression:implications for age-associated increases in inflammation[J].Blood,2009,113(21):5202-5205.
  • 6Cowley MA,Grove KL.Ghrelin-satisfying a hunger for the mechanism[J].Endocrinology,2004,145(6):2604-2646.
  • 7Kotani K,Sakane N,Saiga K,et al.Serum ghrelin and carotid atherosclerosis in older Japanese people with metabolic syndrome[J].Arch Med Res,2006,37(7):903-906.
  • 8Matsumura K,Tsuchihashi T,Fujii K,et al.Central ghrelin modulates sympathetic activity in conscious rabbits[J].Hypertension,2002,40(5):694-699.
  • 9Sharma V,McNeill JH.The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology[J].Curr Vasc Pharmacol,2005,3(2):169-180.
  • 10Lin Y,Matsumura K,Fukuhara M,et al.Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats[J].Hypertension,2004,43(5):977-982.

二级参考文献26

  • 1Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].Nature,1999,402:656-660.
  • 2Broglio F,Gottero C,Prodam F,et al.Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans [J].J Clin Endocrinol Metab,2004,89:3062-3065.
  • 3Nagaya N,Uematsu M,Kojima M,et al.Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic /catabolic factors [J].Circulation,2001,104:2034-2038.
  • 4Takaya K,Ariyasu HK,Kanamoto N,et al.Ghrelin strongly stimulates growthhormone release in humans [J].J Clin Endocrinol Metab,2000,85:4908-4911.
  • 5Cummings DE,Purnell JQ,Frayo RS,et al.A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in human [J].Diabetes,2001,50:1714-1719.
  • 6Baldanzi G,Filigheddu N,Cutrup S,et al.Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cell through ERK1/2 and PI3-kinase/AKT [J].J Cell Biol,2002,159:1029-1037.
  • 7Hunt SA,Baker DM,Chin MN,et al.ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult [J].Circulation,2001,104:2996.
  • 8Wren AM,Small CJ,Ward HL,et al.The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion [J].Endocrinology,2000,141:4325-4328.
  • 9Masuda Y,Tanaka T,Inomata N,et al.Ghrelin stimulates gastric acid secretion and motility in rats [J].Biochem Biophy Res Commun,2000,276:905-908.
  • 10Koo GC,Huang C,Camacho R,et al.Immune enhancing effect of a growth hormone secretagogue [J].J Immunol,2001,166:4195-4201.

共引文献1

同被引文献88

  • 1王锋,刘自刚.血脂、超敏C反应蛋白、D-二聚体、同型半胱氨酸联合检测诊断冠心病的临床意义[J].医学信息（医学与计算机应用）,2014,0(5):75-75. 被引量：6
  • 2Andrea Picchi,Stefano Capobianco,Marta Focardi.Coronary microvascular dysfunction in diabetes mellitus:A review[J].World Journal of Cardiology,2010,2(11):377-390. 被引量：24
  • 3盛敏,任怡春,陈圣国.老年冠心病患者肺炎支原体感染与心脏损伤的关系[J].山东医药,2005,45(1):35-36. 被引量：4
  • 4Masanauskiene E, Naudzifinas A. Peripheral arterial disease - - an underappreciated clinical problem [ J ]. Medicina ( Kaunas ). 2008,44 (4) :328 - 335.
  • 5Hayashi C, Oguwa O, Kubo S, et al. Ankle brachial pressure in- dex and carotid intima - media thickness as atherosclerosis markers in Japanese diabetes [J]. Diabetes Res Clin Pract, 2004,66 (3) : 269 - 275.
  • 6Maiti R, Jaida J, Leander PJ,et al. Cardioproteetive role of insu- lin: Advantage analogues [J]. J Res Med Sei, 2012,17(7) :642 - 648.
  • 7Adamikova A, Rybka J. Up today trends in insulin therapy [ J ]. Vnitr Lek, 2013,59(6) :440 -443.
  • 8Chaudhuri A, Dandona P, Fonseca V. Cardiovascular benefits of exogenous insulin [ J]. J Clin Endocrinol Metab, 2012,97 (9): 3079 - 3091.
  • 9Jandeleit - Dahm KA, Gray SP. Insulin and cardiovascular dis- ease: biomarker or association? [J]. Diabetologia, 2012, 55 (12) :3145 -3151.
  • 10Schernthaner G. Diabetes and Cardiovascular Disease: Is intensive glucose control beneficial or deadly? Lessons from ACCORD, AD- VANCE, VADT, UKPDS, PROactive, and NICE- SUGAR [J]. Wien Med Wochenschr, 2010,160 ( 1 - 2) :8 - 19.

引证文献8

二级引证文献31

心血管病学进展
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部