摘要
目的探讨手术联合米非司酮治疗子宫内膜异位症的临床疗效及安全性。方法将96例子宫内膜异位症患者随机分为观察组和对照组,各48例。2组均采用手术治疗,观察组术后每天口服米非司酮12.5mg,连续3个月;对照组术后不加用任何药物治疗,只作定期随访。所有患者随访6个月,比较2组临床疗效。结果观察组和对照组的总有效率分别为83.3%和54.2%,观察组高于对照组,差异有统计学意义(P<0.01);观察组的复发率为10.4%明显低于对照组的29.2%,差异有统计学意义(P<0.05)。结论手术联合米非司酮治疗子宫内膜异位症的疗效优于单纯手术治疗,且无明显不良反应。
Objective To observe the therapeutic effect and its safety of combining operation with mifepristone in the treatment of endometriosis. Methods 96 cases with endometriosis were randomly divided into observation group and control group. Two groups received operation, in addition, the observation group received orally mifepristone 12.5mg/d for three months;With the control group were without any drug treatment, only for regular follow-up. All cases were followed up for six months and the clinical efficacy were observed. Results The total effectiveness rate of observation group was significantly higher than that of control group（ 83.3% vs 54.2%, P 〈 0.01 ）, while recurrence rate of observation group was significantly lower than that of control group（ 10.4% vs 29.2% ,P 〈 0.05 ）. Conclusion The therapeutic effect of operation combine with mifepristone for endometriosis is superior to that of simple operation with few side reaction.
出处
《临床合理用药杂志》
2010年第10期34-35,共2页
Chinese Journal of Clinical Rational Drug Use
