摘要
目的:探讨乳腺癌患者血清COX-2与ANXA1的表达及其意义。方法:采用ELISA法检测乳腺癌组49例,乳腺良性病变组23例,健康对照组20例血清中COX-2与ANXA1的水平。结果:①乳腺癌血清组COX-2水平高于乳腺良性病变组及健康对照组,而ANXA1则低于乳腺良性病变组及健康对照组,二者在3组间比较差异均有统计学意义(P<0.01);②二者联合检测对乳腺癌诊断灵敏度为95.9%,特异度为48.8%;③COX-2的表达与TNM分期、腋淋巴结转移程度有关;ANXA1的表达与肿瘤直径、TNM分期、腋淋巴结转移程度有关。结论:血清COX-2与ANXA1的水平在一定程度上反映了乳腺癌的生物学特性;二者联合检测可提高乳腺癌诊断的灵敏度,对乳腺癌的早期诊断可能有重要意义。
Objective：To study the expression and significance of serum COX-2 and ANXA1 in breast cancer.Methods：The serum concentration of COX-2 and ANXA1 was detected by enzyme linked immunosorbentassay in three groups.Fourty-nine cases with breast cancer,23 cases with benign breast disease and 20 healthy controls were studied.Results：The concentration of COX-2 in breast cancer group was higher than that in benign breast disease group and healthy group,however,the expression of the ANXA1 was opposite.There was statistical significance in the concentration of COX-2 and ANXA1 among the three groups（P〈0.05）.In combined assay of COX-2 and ANXA1,the sensitivity was 95.9%,the specificity was 48.8%.The expression of COX-2 was associated with patient＇s clinical stages,lymphnode metastasis.The expression of ANXA1 was associated with patient＇s tumor size,clinical stages and lymphnode metastasis.Conclusion：Combined analysis has improved the diagnosis ratio of breast cancer.The expression of COX-2 and ANXA1 are correlated with the biological characteristics of breast cancer,and it may be used as indicators of assessment and prognosis in breast cancer.
出处
《广西医科大学学报》
CAS
2010年第2期244-246,共3页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目(No.桂科自0728143)
