摘要
目的研究omega-3脂肪酸(降血脂辅助药)对高血压合并颈动脉粥样硬化患者血管内皮功能和内膜厚度的影响。方法 62例经颈动脉超声证实存在颈动脉粥样硬化的高血压患者,随机分为2组:对照组(高血压常规治疗)和试验组(高血压常规治疗+omega-3脂肪酸22.5mg每日3次),观察8周,治疗前后测定血清内皮素(ET)、一氧化氮(NO)水平和颈动脉内膜厚度。结果与治疗前比较,对照组ET、NO和颈动脉内膜厚度无明显差异(P>0.05);试验组:ET明显下降而NO显著升高且颈动脉内膜的厚度明显缩小。结论高血压合并颈动脉粥样硬化患者,在常规治疗基础上合用omega-3不饱和脂肪酸,能使患者的血管内皮功能得到一定的改善,能减少颈动脉内膜的厚度,有一定的抗动脉粥样硬化的作用。
Objective To evaluate the effects of omega -3 fatty acids on endothelial （ET） function in hypertension patients with carotid atheresclerosis. Methods Sixty -two hypertension patients with carotid athersclerosis by carotid arterial ultrasound were randomly assigned supplements of omega- 3 fatty acids （22. 5 mg tid and normal treatment, n = 32, trial group）, others received normal treatment （ n = 30, control group）. At the beginning of the treatment and 8 weeks later at the end of the treatment, the plasma ET and nitric oxide （NO） were measured twice. The carotid arterial intima- media thickness （IMT） was measured twice too. Results The plasma ET levels were significantly lowered, NO levels were higher in patients who were treated with omega -3 fatty acids. IMT was significantly reduced. Conclusion Compared with baseline values, the treatment with omega- 3 fatty acids in patients with carotid atheresclerosis helps to improve the endothelial functions, reduce the IMT of the carotid arterial and have the effects of anti - athereselerosis.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2010年第5期330-333,共4页
The Chinese Journal of Clinical Pharmacology
