摘要
目的探讨TPX2 mRNA在食管癌组织中的表达及其与临床病理参数之间的关系。方法运用RT-PCR方法检测62例食管鳞癌组织、对应的31例不典型增生组织TPX2 mRNA的表达与临床病理参数的关系。结果TPX2在正常食管上皮细胞中不表达或者弱表达,食管癌组织中TPX2的表达率为65.5%(40/62),不典型增生组织为35.5%(11/31),TPX2在食管癌组织中的表达显著高于不典型增生组织及正常上皮组织。且表达水平与食管癌的淋巴结转移和浸润深度相关,组间比较差异有统计学意义(P<0.01)。而在不同分级、性别和年龄患者中,TPX2的表达差异无显著性。结论TPX2的表达与食管癌的浸润深度及转移有一定的相关性。
Purpose To explore the expression of TPX2 mRNA in esophageal squamous cell cancer（ESCC） and approch relationship between the TPX2 and clinicopathological characteristic of esophageal squamous cell carcinoma.Methods The expression of TPX2 in 62 specimens of ESCC,paracancer esophageal,epithelia and distant normal esophageal epithelia was detected by reverse transcription-polymerase chain reaction（RT-PCR）.The correlations of TPX2 expression to clinicopathologic features were analyzed in 62 cases of ESCCs.Results The positive rate of TPX2 was significantly higher in ESCC than that in paracancer esophageal epithelia（65.5% vs 35.5%）.The expression of TPX2 was correlated with the histological grade,invasive depth and lymphatic metastasis in esophageal squamous cell carcinoma.There was a significant statistic difference among the groups（P0.01）.The expression of TPX2 had no correlations to grade,sex,and age.Conclusion The expression of TPX2 might be related to with the invasive depth and lymphatic metastasis in esophageal squamous cell carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第2期151-153,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
河南省教育厅自然科学基金(2009A310011)
